Idioma:

Controlled trials in children: quantity, methodological quality and descriptive characteristics of pediatric controlled trials published 1948-2006

Thomson, Denise ; Hartling, Lisa ; Cohen, Eyal ; Vandermeer, Ben ; Tjosvold, Lisa ; Klassen, Terry P Siegfried, Nandi

PloS one, 2010-09, Vol.5 (9), p.e13106 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Controlled trials in children: quantity, methodological quality and descriptive characteristics of pediatric controlled trials published 1948-2006
Autor: Thomson, Denise ; Hartling, Lisa ; Cohen, Eyal ; Vandermeer, Ben ; Tjosvold, Lisa ; Klassen, Terry P
Siegfried, Nandi
Assuntos: Adolescent ; Anesthesia ; Bibliographic data bases ; Child ; Child health ; Child, Preschool ; Children ; Children & youth ; Childrens health ; Clinical trials ; Collaboration ; Controlled Clinical Trials as Topic ; Diagnostic systems ; Disorders ; Drug dosages ; Evidence-Based Healthcare/Statistical Methodologies and Health Informatics ; Female ; Health aspects ; Health care ; Humans ; Infectious diseases ; Male ; Medical research ; Medicine, Experimental ; Mental disorders ; Mental illness ; Motivation ; Neonates ; Non-Clinical Medicine/Research Methods ; Pediatrics ; Pediatrics - methods ; Pediatrics - standards ; Pediatrics and Child Health ; Pharmaceutical industry ; Public health ; Quality ; Randomized Controlled Trials as Topic - standards ; Studies ; Trends
É parte de: PloS one, 2010-09, Vol.5 (9), p.e13106
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Contributed to the conception and design of the review: DT LH EC TK. Supervised the data extraction and interpretation of results: DT. Drafted the manuscript: DT LH EC BV TK. Provided critical revision of the manuscript for important intellectual content: LH EC TK. Contributed to the data synthesis plan and data processing: BV. Carried out the statistical analysis and interpretation: BV. Coordinated the Child Health Field Trials Register: LT. Assisted with extracting the sample for this project: LT. Assisted with manuscript preparation: LT. Obtained funding for the project: TK.
Descrição: The objective of this study was to describe randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in child health published between 1948 and 2006, in terms of quantity, methodological quality, and publication and trial characteristics. We used the Trials Register of the Cochrane Child Health Field for overall trends and a sample from this to explore trial characteristics in more detail. We extracted descriptive data on a random sample of 578 trials. Ninety-six percent of the trials were published in English; the percentage of child-only trials was 90.5%. The most frequent diagnostic categories were infectious diseases (13.2%), behavioural and psychiatric disorders (11.6%), neonatal critical care (11.4%), respiratory disorders (8.9%), non-critical neonatology (7.9%), and anaesthesia (6.5%). There were significantly fewer child-only studies (i.e., more mixed child and adult studies) over time (P = 0.0460). The proportion of RCTs to CCTs increased significantly over time (P<0.0001), as did the proportion of multicentre trials (P = 0.002). Significant increases over time were found in methodological quality (Jadad score) (P<0.0001), the proportion of double-blind studies (P<0.0001), and studies with adequate allocation concealment (P<0.0001). Additionally, we found an improvement in reporting over time: adequate description of withdrawals and losses to follow-up (P<0.0001), sample size calculations (P<0.0001), and intention-to-treat analysis (P<0.0001). However, many trials still do not describe their level of blinding, and allocation concealment was inadequately reported in the majority of studies across the entire time period. The proportion of studies with industry funding decreased slightly over time (P = 0.003), and these studies were more likely to report positive conclusions (P = 0.028). The quantity and quality of pediatric controlled trials has increased over time; however, much work remains to be done, particularly in improving methodological issues around conduct and reporting of trials.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Controlled trials in children: quantity, methodological quality and descriptive characteristics of pediatric controlled trials published 1948-2006

Thomson, Denise ; Hartling, Lisa ; Cohen, Eyal ; Vandermeer, Ben ; Tjosvold, Lisa ; Klassen, Terry P Siegfried, Nandi

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.