Language:

Natural History of Pediatric Intestinal Failure: Initial Report from the Pediatric Intestinal Failure Consortium

Squires, Robert H., MD ; Duggan, Christopher, MD ; Teitelbaum, Daniel H., MD ; Wales, Paul W., MD ; Balint, Jane, MD ; Venick, Robert, MD ; Rhee, Susan, MD ; Sudan, Debra, MD ; Mercer, David, MD ; Martinez, J. Andres, MD ; Carter, Beth A., MD ; Soden, Jason, MD ; Horslen, Simon, MD ; Rudolph, Jeffrey A., MD ; Kocoshis, Samuel, MD ; Superina, Riccardo, MD ; Lawlor, Sharon, MBA ; Haller, Tamara, BS ; Kurs-Lasky, Marcia, MS ; Belle, Steven H., PhD, MScHyg

The Journal of pediatrics, 2012-10, Vol.161 (4), p.723-728.e2 [Peer Reviewed Journal]

Maryland Heights, MO: Elsevier Inc

Full text available

Citations Cited by

Actions
1. Add to e-Shelf
2. Remove from e-Shelf
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Natural History of Pediatric Intestinal Failure: Initial Report from the Pediatric Intestinal Failure Consortium
Author: Squires, Robert H., MD ; Duggan, Christopher, MD ; Teitelbaum, Daniel H., MD ; Wales, Paul W., MD ; Balint, Jane, MD ; Venick, Robert, MD ; Rhee, Susan, MD ; Sudan, Debra, MD ; Mercer, David, MD ; Martinez, J. Andres, MD ; Carter, Beth A., MD ; Soden, Jason, MD ; Horslen, Simon, MD ; Rudolph, Jeffrey A., MD ; Kocoshis, Samuel, MD ; Superina, Riccardo, MD ; Lawlor, Sharon, MBA ; Haller, Tamara, BS ; Kurs-Lasky, Marcia, MS ; Belle, Steven H., PhD, MScHyg
Subjects: Biological and medical sciences ; Enterocolitis, Necrotizing - epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroschisis - epidemiology ; General aspects ; Hirschsprung Disease - epidemiology ; Humans ; Infant ; Intestinal Atresia - epidemiology ; Intestinal Diseases - epidemiology ; Intestinal Diseases - mortality ; Intestinal Diseases - surgery ; Intestinal Diseases - therapy ; Intestinal Volvulus - epidemiology ; Intestines - transplantation ; Male ; Medical sciences ; Other diseases. Semiology ; Parenteral Nutrition ; Pediatrics ; Prognosis ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Is Part Of: The Journal of pediatrics, 2012-10, Vol.161 (4), p.723-728.e2
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
List of key members of the Pediatric Intestinal Failure Consortium is available at www.jpeds.com (Appendix).
Description: Objective To characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era. Study design The Pediatric Intestinal Failure Consortium performed a retrospective analysis of clinical and outcome data for a multicenter cohort of infants with IF. Entry criteria included infants <12 months receiving parenteral nutrition (PN) for >60 continuous days. Enteral autonomy was defined as discontinuation of PN for >3 consecutive months. Values are presented as median (25th, 75th percentiles) or as number (%). Results 272 infants with a gestational age of 34 weeks (30, 36) and birth weight of 2.1 kg (1.2, 2.7) were followed for 25.7 months (11.2, 40.9). Residual small bowel length in 144 patients was 41 cm (25.0, 65.5). Diagnoses were necrotizing enterocolitis (71, 26%), gastroschisis (44, 16%), atresia (27, 10%), volvulus (24, 9%), combinations of these diagnoses (46, 17%), aganglionosis (11, 4%), and other single or multiple diagnoses (48, 18%). Prescribed medications included oral antibiotics (207, 76%), H2 blockers (187, 69%), and proton pump inhibitors (156, 57%). Enteral feeding approaches varied among centers; 19% of the cohort received human milk. The cohort experienced 8.9 new catheter-related blood stream infections per 1000 catheter days. The cumulative incidences for enteral autonomy, death, and intestinal transplantation were 47%, 27%, and 26%, respectively. Enteral autonomy continued into the fifth year after study entry. Conclusions Children with IF endure significant mortality and morbidity. Enteral autonomy may require years to achieve. Improved medical, nutritional, and surgical management may reduce time on PN, mortality, and need for transplantation.
Publisher: Maryland Heights, MO: Elsevier Inc
Language: English

Links

Back to results list

Previous Result 7 Next Go to Next page

Implemented by: Social Network Logos:

Natural History of Pediatric Intestinal Failure: Initial Report from the Pediatric Intestinal Failure Consortium

Maryland Heights, MO: Elsevier Inc

Searching Remote Databases, Please Wait