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Morphologic and Molecular Characterization of Traditional Serrated Adenomas of the Distal Colon and Rectum

Wiland, Homer O ; Shadrach, Bonnie ; Allende, Daniela ; Carver, Paula ; Goldblum, John R ; Liu, Xiuli ; Patil, Deepa T ; Rybicki, Lisa A ; Pai, Rish K

The American journal of surgical pathology, 2014-09, Vol.38 (9), p.1290-1297 [Periódico revisado por pares]

United States: by Lippincott Williams & Wilkins

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Título:
Morphologic and Molecular Characterization of Traditional Serrated Adenomas of the Distal Colon and Rectum
Autor: Wiland, Homer O ; Shadrach, Bonnie ; Allende, Daniela ; Carver, Paula ; Goldblum, John R ; Liu, Xiuli ; Patil, Deepa T ; Rybicki, Lisa A ; Pai, Rish K
Assuntos: Adenoma - chemistry ; Adenoma - diagnosis ; Adenoma - genetics ; Adenoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Annexins - analysis ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Biopsy ; Chromogranins ; Colonic Neoplasms - chemistry ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - genetics ; Colonic Neoplasms - pathology ; Colonic Polyps - chemistry ; Colonic Polyps - diagnosis ; Colonic Polyps - genetics ; Colonic Polyps - pathology ; CpG Islands ; DNA Methylation ; DNA Mutational Analysis ; Female ; Genetic Predisposition to Disease ; GTP-Binding Protein alpha Subunits, Gs - genetics ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mutation ; Ohio ; Phenotype ; Prognosis ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins B-raf - genetics ; Proto-Oncogene Proteins p21(ras) ; ras Proteins - genetics ; Rectal Neoplasms - chemistry ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - genetics ; Rectal Neoplasms - pathology
É parte de: The American journal of surgical pathology, 2014-09, Vol.38 (9), p.1290-1297
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SourceType-Scholarly Journals-1
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Descrição: Of the serrated polyps, the origin, morphologic features, molecular alterations, and natural history of traditional serrated adenomas (TSAs) are the least understood. Recent studies suggest that these polyps may arise from precursor lesions. The frequencies of KRAS and BRAF mutations vary between these studies, and only 1 small study has measured CpG island methylation using current markers of methylation. Mutations in GNAS, a gene commonly mutated in colorectal villous adenomas, have not been fully evaluated in TSAs. Finally, the expression of annexin A10 (ANXA10), a recently discovered marker of sessile serrated adenomas/polyps, has not been studied in these polyps. To further characterize these polyps, 5 gastrointestinal pathologists reviewed 55 left-sided polyps diagnosed as TSA at a single institution. Pathologists assessed various histologic features including cytoplasmic eosinophilia, ectopic crypt foci, presence of conventional dysplasia, and presence of precursor serrated lesions. KRAS, BRAF, and GNAS mutational analysis was performed, as well as CpG island methylation and ANXA10 immunohistochemistry. Ectopic crypt foci were seen in 62% of TSAs. Precursor lesions were seen in 24% of the study polyps, most of which were hyperplastic polyps. KRAS and BRAF mutations were common and were present in 42% and 48% of polyps, respectively. GNAS mutations occurred in 8% of polyps, often in conjunction with a BRAF mutation. Unlike sessile serrated adenomas/polyps, TSAs rarely had diffuse expression of ANXA10. Importantly, BRAF-mutated TSAs had more widespread methylation of a 5-marker CpG island panel compared with KRAS-mutated polyps. However, ectopic crypt foci, a proposed defining feature of TSA, were not associated with any specific molecular alteration.
Editor: United States: by Lippincott Williams & Wilkins
Idioma: Inglês

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Morphologic and Molecular Characterization of Traditional Serrated Adenomas of the Distal Colon and Rectum

Wiland, Homer O ; Shadrach, Bonnie ; Allende, Daniela ; Carver, Paula ; Goldblum, John R ; Liu, Xiuli ; Patil, Deepa T ; Rybicki, Lisa A ; Pai, Rish K

United States: by Lippincott Williams & Wilkins

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