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Methadone versus buprenorphine: data detected from Caltanissetta SER.T

Venturella, Fabio ; Cancellieri, Giulia ; Giammanco, Marco ; Liga, Anastasia Valentina ; Mortillaro, Francesca ; Di Carlo, Annamaria

Journal of Biological Research, 2020-07, Vol.93 (1) [Periódico revisado por pares]

Pavia: PAGEPress Publications

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  • Título:
    Methadone versus buprenorphine: data detected from Caltanissetta SER.T
  • Autor: Venturella, Fabio ; Cancellieri, Giulia ; Giammanco, Marco ; Liga, Anastasia Valentina ; Mortillaro, Francesca ; Di Carlo, Annamaria
  • Assuntos: Buprenorphine ; Heroin ; Methadone ; suboxone
  • É parte de: Journal of Biological Research, 2020-07, Vol.93 (1)
  • Descrição: In last years, heroin-addicted have exponentially increased: this has made it necessary to identify a pharmacological strategy as effective as possible. With this purpose, a statistical investigation was conducted in a sample of individuals, aged between 18 and 50. They were diagnosed and subjected to different treatments at Ser.T of Caltanissetta (Sicily-Italy) during the period 2013-2017. The analyzed patients were treated with three different pharmacological therapy: methadone 0.1%, methadone 0.5%, buprenorphine and suboxone. We obtained percentages of responders, low responders and non-responders patients from data processing, based on used therapy. Considering pharmacological responses of the sample examined, it is possible to observe that the treatment with buprenorphine has led to 71.98% of responders subjects, 23.52% of low responders and 4.5% of non-responders. Instead, the administration of methadone 0.1 % has produced 82.82% of responders subjects, 11.08% of low responders, 6.1% of nonresponders. The therapy with methadone 0.5% has resulted 88.98% of responders subjects, 7.8% of low responders, 3.22% of nonresponders. Finally, through the administration of suboxone, we obtained 86.34% of responders subjects, 9.84% of low responders and 3.82% of non responders. In conclusion, although it has emerged that treatment with methadone 0.5% is the most successful therapy, it is preferable to use suboxone (except in relapsing subjects) since it has also produced a high number of responders subjects and a good safety profile for heroin addicted patients.
  • Editor: Pavia: PAGEPress Publications
  • Idioma: Inglês;Italiano
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