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Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer

Rozich, Noah S ; Lewis, Samara E ; Chen, Sixia ; Stewart, Kenneth E ; Stout, Michael B ; Dooley, William C ; Fischer, Laura E ; Morris, Katherine T Chou, Wen-Chi

PloS one, 2021-04, Vol.16 (4), p.e0250726-e0250726 [Periódico revisado por pares]

United States: Public Library of Science

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  • Título:
    Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer
  • Autor: Rozich, Noah S ; Lewis, Samara E ; Chen, Sixia ; Stewart, Kenneth E ; Stout, Michael B ; Dooley, William C ; Fischer, Laura E ; Morris, Katherine T
  • Chou, Wen-Chi
  • Assuntos: Biology and Life Sciences ; Cancer ; Care and treatment ; Demographic aspects ; Medicine and Health Sciences
  • É parte de: PloS one, 2021-04, Vol.16 (4), p.e0250726-e0250726
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Competing Interests: The authors have declared that no competing interests exist.
  • Descrição: We hypothesize that women undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis from appendiceal cancer will have a survival advantage compared to men. The National Cancer Database (NCDB) public user file (2004-2014) was used to select patients with PC undergoing CRS and HIPEC from appendiceal cancer. Univariate and multivariable analyses were performed. 1,190 patients with PC from appendiceal cancer underwent HIPEC and CRS. OS was significantly longer for women than for men, with mean and median OS being 73.8 months and 98.2 months for women vs 58.7 months and 82.5 months for men, respectively (p = 0.0032). On multivariable analysis, male sex (HR: 1.444, 95% CI: 1.141-1.827, p = 0.0022) and increasing age (HR: 1.017, 95% CI: 1.006-1.027, p = 0.0017) were both found to be independent risk factors for worse OS. Women undergoing CRS and HIPEC for PC from appendiceal origin live longer than men undergoing the same treatment. Increasing age was also found to be independent risk factors for worse survival.
  • Editor: United States: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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