Idioma:

TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss

Lelis Carvalho, Adriana ; Treyball, Annika ; Brooks, Daniel J ; Costa, Samantha ; Neilson, Ryan J ; Reagan, Michaela R ; Bouxsein, Mary L ; Motyl, Katherine J Villena, Josep A.

PloS one, 2021-06, Vol.16 (6), p.e0231060-e0231060 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss
Autor: Lelis Carvalho, Adriana ; Treyball, Annika ; Brooks, Daniel J ; Costa, Samantha ; Neilson, Ryan J ; Reagan, Michaela R ; Bouxsein, Mary L ; Motyl, Katherine J
Villena, Josep A.
Assuntos: Adipose Tissue, Brown - metabolism ; Adipose Tissue, Brown - physiopathology ; Animals ; Biology and Life Sciences ; Body temperature ; Body Temperature Regulation - physiology ; Bone and Bones - metabolism ; Bone and Bones - physiopathology ; Bone Diseases - metabolism ; Bone Diseases - physiopathology ; Bones ; Cell receptors ; Cold Temperature ; Energy Metabolism - physiology ; Female ; Male ; Medicine and Health Sciences ; Mice ; Mice, Knockout ; Physiological aspects ; Regulation ; Thermogenesis - physiology ; TRPM Cation Channels - metabolism ; Uncoupling Protein 1 - metabolism
É parte de: PloS one, 2021-06, Vol.16 (6), p.e0231060-e0231060
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Trpm8 (transient receptor potential cation channel, subfamily M, member 8) is expressed by sensory neurons and is involved in the detection of environmental cold temperatures. TRPM8 activity triggers an increase in uncoupling protein 1 (Ucp1)-dependent brown adipose tissue (BAT) thermogenesis. Bone density and marrow adipose tissue are both influenced by rodent housing temperature and brown adipose tissue, but it is unknown if TRPM8 is involved in the co-regulation of thermogenesis and bone homeostasis. To address this, we examined the bone phenotypes of one-year-old Trpm8 knockout mice (Trpm8-KO) after a 4-week cold temperature challenge. Male Trpm8-KO mice had lower bone mineral density than WT, with smaller bone size (femur length and cross-sectional area) being the most striking finding, and exhibited a delayed cold acclimation with increased BAT expression of Dio2 and Cidea compared to WT. In contrast to males, female Trpm8-KO mice had low vertebral bone microarchitectural parameters, but no genotype-specific alterations in body temperature. Interestingly, Trpm8 was not required for cold-induced trabecular bone loss in either sex, but bone marrow adipose tissue in females was significantly suppressed by Trpm8 deletion. In summary, we identified sex differences in the role of TRPM8 in maintaining body temperature, bone microarchitecture and marrow adipose tissue. Identifying mechanisms through which cold temperature and BAT influence bone could help to ameliorate potential bone side effects of obesity treatments designed to stimulate thermogenesis.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss

Lelis Carvalho, Adriana ; Treyball, Annika ; Brooks, Daniel J ; Costa, Samantha ; Neilson, Ryan J ; Reagan, Michaela R ; Bouxsein, Mary L ; Motyl, Katherine J Villena, Josep A.

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.