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Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K

Abbott, Caroline A ; Malik, Rayaz A ; van Ross, Ernest R.E ; Kulkarni, Jai ; Boulton, Andrew J.M

Diabetes care, 2011-10, Vol.34 (10), p.2220-2224 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K
Autor: Abbott, Caroline A ; Malik, Rayaz A ; van Ross, Ernest R.E ; Kulkarni, Jai ; Boulton, Andrew J.M
Assuntos: Administration, Oral ; Adult ; Age Distribution ; Aged ; alcohols ; Asians ; Biological and medical sciences ; Clinics ; Data collection ; Diabetes ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Diabetic neuropathies ; Diabetic Neuropathies - epidemiology ; Diabetic Neuropathies - ethnology ; Diabetic Neuropathies - pathology ; Diabetic neuropathy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Europeans ; Family medical history ; Female ; health services ; Hospitals ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - therapeutic use ; insulin ; insulin-dependent diabetes mellitus ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; men ; Metabolic diseases ; Middle Aged ; Miscellaneous ; morbidity ; noninsulin-dependent diabetes mellitus ; observational studies ; odds ratio ; Original Research ; patients ; Prevalence studies (Epidemiology) ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; risk ; screening ; Sex Factors ; United Kingdom - epidemiology ; women
É parte de: Diabetes care, 2011-10, Vol.34 (10), p.2220-2224
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: OBJECTIVE: To assess, in the general diabetic population, 1) the prevalence of painful neuropathic symptoms; 2) the relationship between symptoms and clinical severity of neuropathy; and 3) the role of diabetes type, sex, and ethnicity in painful neuropathy. RESEARCH DESIGN AND METHODS: Observational study of a large cohort of diabetic patients receiving community-based health care in northwest England (n = 15,692). Painful diabetic neuropathy (PDN) was assessed using neuropathy symptom score (NSS) and neuropathy disability score (NDS). RESULTS: Prevalence of painful symptoms (NSS ≥5) and PDN (NSS ≥5 and NDS ≥3) was 34 and 21%, respectively. Painful symptoms occurred in 26% of patients without neuropathy (NDS ≤2) and 60% of patients with severe neuropathy (NDS >8). Adjusted risk of painful neuropathic symptoms in type 2 diabetes was double that of type 1 diabetes (odds ratio [OR] = 2.1 [95% CI 1.7–2.4], P < 0.001) and not affected by severity of neuropathy, insulin use, foot deformities, smoking, or alcohol. Women had 50% increased adjusted risk of painful symptoms compared with men (OR = 1.5 [1.4–1.6], P < 0.0001). Despite less neuropathy in South Asians (14%) than Europeans (22%) and African Caribbeans (21%) (P < 0.0001), painful symptoms were greater in South Asians (38 vs. 34 vs. 32%, P < 0.0001). South Asians without neuropathy maintained a 50% increased risk of painful neuropathy symptoms compared with other ethnic groups (P < 0.0001). CONCLUSIONS: One-third of all community-based diabetic patients have painful neuropathy symptoms, regardless of their neuropathic deficit. PDN was more prevalent in patients with type 2 diabetes, women, and people of South Asian origin. This highlights a significant morbidity due to painful neuropathy and identifies key groups who warrant screening for PDN.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K

Abbott, Caroline A ; Malik, Rayaz A ; van Ross, Ernest R.E ; Kulkarni, Jai ; Boulton, Andrew J.M

Alexandria, VA: American Diabetes Association

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