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A randomized, multicenter study of G-CSF starting on day +1 vs day +5 after autologous peripheral blood progenitor cell transplantation

DE AZEVEDO, A. M ; NUCCI, M ; MAIOLINO, A ; VIGORITO, A. C ; SIMOES, B. P ; ARANHA, F. J. P ; TABAK, D. G ; VOLTARELLI, J ; DE SOUZA, C. A

Bone marrow transplantation (Basingstoke), 2002-05, Vol.29 (9), p.745-751 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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A randomized, multicenter study of G-CSF starting on day +1 vs day +5 after autologous peripheral blood progenitor cell transplantation
Autor: DE AZEVEDO, A. M ; NUCCI, M ; MAIOLINO, A ; VIGORITO, A. C ; SIMOES, B. P ; ARANHA, F. J. P ; TABAK, D. G ; VOLTARELLI, J ; DE SOUZA, C. A
Assuntos: Adolescent ; Adult ; Aged ; Antibiotics ; Autografts ; Biological and medical sciences ; Blood ; Bone marrow ; CD34 antigen ; Cells (biology) ; Drug Administration Schedule ; Engraftment ; Female ; Fever ; Fever - etiology ; Fever - prevention & control ; Graft Survival - drug effects ; Granulocyte colony-stimulating factor ; Granulocyte Colony-Stimulating Factor - administration & dosage ; Granulocyte Colony-Stimulating Factor - pharmacology ; Hematologic and hematopoietic diseases ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - therapy ; Hematopoiesis - drug effects ; Hemopoiesis ; Humans ; Leukocytes (neutrophilic) ; Male ; Medical sciences ; Melphalan ; Middle Aged ; Multivariate analysis ; Neutropenia ; Neutropenia - prevention & control ; Neutrophils ; Other diseases. Hematologic involvement in other diseases ; Patients ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation - adverse effects ; Peripheral Blood Stem Cell Transplantation - methods ; Progenitor cells ; Prospective Studies ; Stem cell transplantation ; Transplantation ; Transplantation, Autologous - adverse effects ; Transplantation, Autologous - methods ; Transplants & implants ; Treatment Outcome
É parte de: Bone marrow transplantation (Basingstoke), 2002-05, Vol.29 (9), p.745-751
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
Descrição: In order to assess the effect of delaying G-CSF administration after autologous peripheral blood progenitor cell (PBPC) transplantation on the duration of neutropenia, 87 patients were randomized to receive G-CSF 5 microg/kg/day starting on day +1 (n = 45) or +5 (n = 42) following PBPC transplantation, until recovery of the neutrophils. The duration of neutropenia (<0.5 x 10(9)/l) was shorter in the day +1 group (7 vs 8 days; P = 0.02), especially in patients receiving melphalan 200 mg/m(2) and CD34(+) cell doses >3.0 x 10(6)/kg. These patients had a later onset of neutropenia after transplant. There were no differences in time to neutrophil and platelet engraftment, or in the incidence of fever and documentation of infection. Although the duration of antibiotic therapy (7 vs 10.5 days; P = 0.01) and time to hospital discharge (13 vs 15 days; P = 0.02) were shorter in the day +1 group, these differences could not be predicted by the day of G-CSF initiation in multivariate analysis. Starting G-CSF on day +1 does not result in faster neutrophil engraftment but in later onset and consequently, slightly shorter duration of neutropenia in patients who receive melphalan 200 mg/m(2) and CD34(+) cell doses >3.0 x 10(6)/kg.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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A randomized, multicenter study of G-CSF starting on day +1 vs day +5 after autologous peripheral blood progenitor cell transplantation

DE AZEVEDO, A. M ; NUCCI, M ; MAIOLINO, A ; VIGORITO, A. C ; SIMOES, B. P ; ARANHA, F. J. P ; TABAK, D. G ; VOLTARELLI, J ; DE SOUZA, C. A

Basingstoke: Nature Publishing Group

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