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Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons

Muchardt, Christian ; Saint-André, Violaine ; Batsché, Eric ; Rachez, Christophe

Nature structural & molecular biology, 2011-03, Vol.18 (3), p.337-344 [Periódico revisado por pares]

United States: Nature Publishing Group

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Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons
Autor: Muchardt, Christian ; Saint-André, Violaine ; Batsché, Eric ; Rachez, Christophe
Assuntos: Alternative Splicing ; Biochemistry, Molecular Biology ; Cell Line ; Chromosomal Proteins, Non-Histone - metabolism ; Exon (Molecular genetics) ; Exons ; HeLa Cells ; Histones - metabolism ; Humans ; Hyaluronan Receptors - genetics ; Life Sciences ; Lysine - metabolism ; Messenger RNA ; Methylation ; Molecular biology ; Physiological aspects ; RNA Polymerase II - metabolism ; RNA Precursors - metabolism ; RNA splicing ; Structure
É parte de: Nature structural & molecular biology, 2011-03, Vol.18 (3), p.337-344
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Descrição: Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore conceivable that chromatin-borne information participates in alternative splicing. Here we find that elevated levels of trimethylation of histone H3 on Lys9 (H3K9me3) are a characteristic of the alternative exons of several genes including CD44. On this gene the chromodomain protein HP1γ, frequently defined as a transcriptional repressor, facilitates inclusion of the alternative exons via a mechanism involving decreased RNA polymerase II elongation rate. In addition, accumulation of HP1γ on the variant region of the CD44 gene stabilizes association of the pre-mRNA with the chromatin. Altogether, our data provide evidence for localized histone modifications impacting alternative splicing. They further implicate HP1γ as a possible bridging molecule between the chromatin and the maturating mRNA, with a general impact on splicing decisions.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons

Muchardt, Christian ; Saint-André, Violaine ; Batsché, Eric ; Rachez, Christophe

United States: Nature Publishing Group

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