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Molecular and genetic studies of Fusarium trichothecene biosynthesis: Pathways, genes, and evolution

Kimura, M.(Institute of Physical and Chemical Research, Wako, Saitama (Japan).) ; Tokai, T ; Takahashi Ando, N ; Ohsato, S ; Fujimura, M

Bioscience, biotechnology, and biochemistry, 2007, Vol.71 (9), p.2105-2123 [Periódico revisado por pares]

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Título:
Molecular and genetic studies of Fusarium trichothecene biosynthesis: Pathways, genes, and evolution
Autor: Kimura, M.(Institute of Physical and Chemical Research, Wako, Saitama (Japan).) ; Tokai, T ; Takahashi Ando, N ; Ohsato, S ; Fujimura, M
Assuntos: Animals ; Awards and Prizes ; BIOCHEMICAL PATHWAYS ; Biological and medical sciences ; biosynthesis gene cluster ; Biosynthetic Pathways ; CEREALE ; CEREALES ; CEREALS ; EVOLUCION ; EVOLUTION ; Evolution, Molecular ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; fungal secondary metabolism ; Fusarium ; Fusarium - chemistry ; Fusarium - genetics ; Fusarium - metabolism ; Fusarium graminearum (Gibberella zeae) ; GENE ; GENES ; GIBBERELLA ZEAE ; MICOTOXINAS ; MYCOTOXINE ; MYCOTOXINS ; sesquiterpene ; TRICHOTHECENE ; trichothecene mycotoxins ; TRICHOTHECENES ; Trichothecenes - biosynthesis ; Trichothecenes - chemistry ; VIA BIOQUIMICA DEL METABOLISMO ; VOIE BIOCHIMIQUE DU METABOLISME
É parte de: Bioscience, biotechnology, and biochemistry, 2007, Vol.71 (9), p.2105-2123
Notas: F30
J11
Q03
2008001303
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Trichothecenes are a large family of sesquiterpenoid secondary metabolites of Fusarium species (e.g., F. graminearum) and other molds. They are major mycotoxins that can cause serious problems when consumed via contaminated cereal grains. In the past 20 years, an outline of the trichothecene biosynthetic pathway has been established based on the results of precursor feeding experiments and blocked mutant analyses. Following the isolation of the pathway gene Tri5 encoding the first committed enzyme trichodiene synthase, 10 biosynthesis genes (Tri genes; two regulatory genes, seven pathway genes, and one transporter gene) were functionally identified in the Tri5 gene cluster. At least three pathway genes, Tri101 (separated alone), and Tri1 and Tri16 (located in the Tri1-Tri16 two-gene cluster), were found outside of the Tri5 gene cluster. In this review, we summarize the current understanding of the pathways of biosynthesis, the functions of cloned Tri genes, and the evolution of Tri genes, focusing on Fusarium species.
Editor: Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Idioma: Inglês

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Molecular and genetic studies of Fusarium trichothecene biosynthesis: Pathways, genes, and evolution

Kimura, M.(Institute of Physical and Chemical Research, Wako, Saitama (Japan).) ; Tokai, T ; Takahashi Ando, N ; Ohsato, S ; Fujimura, M

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

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