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Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping

Agostino, Mark ; Yuriev, Elizabeth ; Ramsland, Paul A Kobe, Bostjan

PloS one, 2012-04, Vol.7 (4), p.e35457-e35457 [Revista revisada por pares]

United States: Public Library of Science

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Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping
Autor: Agostino, Mark ; Yuriev, Elizabeth ; Ramsland, Paul A
Kobe, Bostjan
Materias: Acids ; Alzheimer's disease ; Alzheimers disease ; Amino Acid Motifs ; Amino Acid Sequence ; Antibodies ; Antibodies, Neoplasm - chemistry ; Antigenic determinants ; Antigens ; Binding sites ; Binding Sites, Antibody ; Biology ; Cancer ; Cancer immunotherapy ; Carbohydrates ; Computer Simulation ; Consortia ; Epitope Mapping ; Flexibility ; Gangliosides ; Gangliosides - chemistry ; Gangliosides - immunology ; Guillain-Barre syndrome ; Humans ; Hydrogen Bonding ; Immune response ; Immune system ; Immunoglobulins ; Immunology ; Immunotherapy ; Investigations ; Ligands ; Medicine ; Melanoma ; Mimicry ; Models, Molecular ; Molecular Sequence Data ; Neoplasms - immunology ; Nervous system ; Peptide mapping ; Peptides ; Peptides - chemistry ; Pharmaceutical sciences ; Protein Binding ; Proteins ; Recognition ; Studies ; Surface Properties ; Viral antibodies
Es parte de: PloS one, 2012-04, Vol.7 (4), p.e35457-e35457
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: MA EY PAR. Performed the experiments: MA. Analyzed the data: MA. Wrote the paper: MA EY PAR.
Descripción: Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high flexibility of these ligands. In this study, we apply our previously developed site mapping technique to investigate the recognition of cancer-related gangliosides by anti-ganglioside antibodies. The results reveal a potential ganglioside-binding motif in the four antibodies studied, suggesting the possibility of structural convergence in the anti-ganglioside immune response. The structural basis of the recognition of ganglioside-mimetic peptides is also investigated using site mapping and compared to ganglioside recognition. The peptides are shown to act as structural mimics of gangliosides by interacting with many of the same binding site residues as the cognate carbohydrate epitopes. These studies provide important clues as to the structural basis of immunological mimicry of carbohydrates.
Editor: United States: Public Library of Science
Idioma: Inglés

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Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping

Agostino, Mark ; Yuriev, Elizabeth ; Ramsland, Paul A Kobe, Bostjan

United States: Public Library of Science

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