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Focal cortical and subcortical atrophy in early Parkinson's disease

Tinaz, Sule ; Courtney, Maureen G. ; Stern, Chantal E.

Movement disorders, 2011-02, Vol.26 (3), p.436-441 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Focal cortical and subcortical atrophy in early Parkinson's disease
Autor: Tinaz, Sule ; Courtney, Maureen G. ; Stern, Chantal E.
Assuntos: Aged ; Atrophy - etiology ; Atrophy - pathology ; Biological and medical sciences ; Brain Mapping ; Cerebral Cortex - pathology ; cognition ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; emotional dysregulation ; Female ; Functional Laterality ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mental Status Schedule ; Middle Aged ; Movement disorders ; MRI ; Neurology ; Neuropsychological Tests ; orbitofrontal cortex ; Parkinson Disease - complications ; Parkinson Disease - pathology ; Severity of Illness Index ; Statistics as Topic
É parte de: Movement disorders, 2011-02, Vol.26 (3), p.436-441
Notas: ArticleID:MDS23453
Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
NIMH award - No. R21 MH066213
Athinoula A. Martinos Center for Biomedical Imaging award - No. NCRR P41 RR14075
ark:/67375/WNG-H3D78T37-L
istex:2AE71BA127E473305F819B0AF90A95913474057E
Relevant conflicts of interest/financial disclosures
Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
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Descrição: Neurodegeneration in clinically manifest Parkinson's disease affects the substantia nigra pars compacta, and gradually spreads to the limbic cortices and the neocortex. We used MRI imaging coupled with automated surface reconstruction and segmentation methods to examine cortical thickness and subcortical volumes in nondemented, early‐stage Parkinson's disease patients compared to matched healthy control participants. These methods, which have been previously used to document cortical thickness changes in patients with Alzheimer's disease and Huntington's disease but not Parkinson's disease, use MR signal intensity information and the geometric constraints of the cortical and subcortical structures for an accurate tissue classification. Parkinson's disease patients were matched to the control group in psychomotor processing speed and executive functioning, but showed higher anxiety state scores. Our results demonstrated focal cortical thinning in the Parkinson's disease group in the orbitofrontal cortex, ventrolateral prefrontal cortex, and occipito‐parietal areas. Subcortically, striatal volume loss was noted. These results demonstrate that both cortical and subcortical structural changes occur at relatively early stages of the disease, and are discussed in terms of the emotional dysregulation that occurs early on in patients with Parkinson's disease. © 2010 Movement Disorder Society
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Focal cortical and subcortical atrophy in early Parkinson's disease

Tinaz, Sule ; Courtney, Maureen G. ; Stern, Chantal E.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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