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Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

de Miguel-Yanes, Jose M ; Shrader, Peter ; Pencina, Michael J ; Fox, Caroline S ; Manning, Alisa K ; Grant, Richard W ; Dupuis, Josèe ; Florez, Jose C ; D'Agostino, Ralph B. Sr ; Cupples, L. Adrienne ; Meigs, James B

Diabetes care, 2011-01, Vol.34 (1), p.121-125 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms
Autor: de Miguel-Yanes, Jose M ; Shrader, Peter ; Pencina, Michael J ; Fox, Caroline S ; Manning, Alisa K ; Grant, Richard W ; Dupuis, Josèe ; Florez, Jose C ; D'Agostino, Ralph B. Sr ; Cupples, L. Adrienne ; Meigs, James B
Assuntos: Adult ; Age ; Biological and medical sciences ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gene loci ; Genetic aspects ; Genetic diversity ; Genetic Predisposition to Disease - genetics ; Genetic research ; Genetics ; Health risk assessment ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Odds Ratio ; Original Research ; Polymorphism, Single Nucleotide - genetics ; Progeny ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reclassification ; Regression analysis ; Risk factors ; Single-nucleotide polymorphism ; Statistics ; Type 2 diabetes
É parte de: Diabetes care, 2011-01, Vol.34 (1), p.121-125
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MAGIC and DIAGRAM+ Investigators are listed in supplementary Table A5 in the online appendix available at http://care.diabetesjournals.org/cgi/content/full/dc10-1265/DC1.
Descrição: OBJECTIVE: To test if knowledge of type 2 diabetes genetic variants improves disease prediction. RESEARCH DESIGN AND METHODS: We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. RESULTS: In people <50 years of age, the clinical risk factors model C-statistic was 0.908; the 40-SNP score increased it to 0.911 (P = 0.3; net reclassification improvement (NRI): 10.2%, P = 0.001). In people ≥50 years of age, the C-statistics without and with the score were 0.883 and 0.884 (P = 0.2; NRI: 0.4%). The risk per risk allele was higher in people <50 than ≥50 years of age (24 vs. 11%; P value for age interaction = 0.02). CONCLUSIONS: Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

de Miguel-Yanes, Jose M ; Shrader, Peter ; Pencina, Michael J ; Fox, Caroline S ; Manning, Alisa K ; Grant, Richard W ; Dupuis, Josèe ; Florez, Jose C ; D'Agostino, Ralph B. Sr ; Cupples, L. Adrienne ; Meigs, James B

Alexandria, VA: American Diabetes Association

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