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Increased expression of CCL20 in human inflammatory bowel disease

Kaser, Arthur ; Ludwiczek, Othmar ; Holzmann, Sandra ; Moschen, Alexander R ; Weiss, Günter ; Enrich, Barbara ; Graziadei, Ivo ; Dunzendorfer, Stefan ; Wiedermann, Christian J ; Mürzl, Elisabeth ; Grasl, Eveline ; Jasarevic, Zerina ; Romani, Nikolaus ; Offner, Felix A ; Tilg, Herbert

Journal of Clinical Immunology, 2004-01, Vol.24 (1), p.74-85 [Periódico revisado por pares]

Netherlands: Springer Nature B.V

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Título:
Increased expression of CCL20 in human inflammatory bowel disease
Autor: Kaser, Arthur ; Ludwiczek, Othmar ; Holzmann, Sandra ; Moschen, Alexander R ; Weiss, Günter ; Enrich, Barbara ; Graziadei, Ivo ; Dunzendorfer, Stefan ; Wiedermann, Christian J ; Mürzl, Elisabeth ; Grasl, Eveline ; Jasarevic, Zerina ; Romani, Nikolaus ; Offner, Felix A ; Tilg, Herbert
Assuntos: Adult ; Antibodies - immunology ; Antibodies - metabolism ; Antigens, CD ; Antigens, Surface - immunology ; Antigens, Surface - metabolism ; Biopsy ; Chemokine CCL20 ; Chemokines, CC - genetics ; Chemokines, CC - immunology ; Chemokines, CC - metabolism ; Colitis, Ulcerative - genetics ; Colitis, Ulcerative - immunology ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - pathology ; Crohn Disease - genetics ; Crohn Disease - immunology ; Crohn Disease - metabolism ; Crohn Disease - pathology ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Epithelium - immunology ; Epithelium - metabolism ; Epithelium - pathology ; Female ; Humans ; Lectins, C-Type - immunology ; Lectins, C-Type - metabolism ; Macrophage Inflammatory Proteins - genetics ; Macrophage Inflammatory Proteins - immunology ; Macrophage Inflammatory Proteins - metabolism ; Male ; Mannose-Binding Lectins - immunology ; Mannose-Binding Lectins - metabolism ; Middle Aged ; Receptors, CCR6 ; Receptors, Chemokine - immunology ; Receptors, Chemokine - metabolism ; RNA, Messenger - metabolism ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Journal of Clinical Immunology, 2004-01, Vol.24 (1), p.74-85
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SourceType-Scholarly Journals-1
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Descrição: Inflammatory bowel disease (IBD) constituting Crohn's disease (CD) and ulcerative colitis (UC) is related to a dysregulated T cell response. CCL20 attracts memory T lymphocytes and dendritic cells. We asked whether CCL20 expression is altered in IBD. Colonic biopsies were obtained from 114 subjects with IBD, non-IBD colitis, irritable bowel syndrome, and healthy controls. CCL20 and CCR6 mRNA expression was measured by Taqman-PCR, and protein secretion from colonic explant cultures (CEC) and its regulation by TNF-alpha by ELISA. CCL20, CCR6, and Langerin were identified by immunohistochemistry and immunofluorescence. CCL20 mRNA and protein were severalfold increased in involved CD and UC but not in non-IBD colitis. TNF-alpha increased and anti-TNF-alpha decreased CCL20 release in healthy control CEC but not in involved IBD colonic specimens. CCL20 localized to follicle-associated epithelium, and CCR6 to the adjacent mantle zone of lymphoid follicles. Furthermore, abundant numbers of Langerin(+) immature dendritic cells were identified in the subepithelial space of IBD specimens. CCL20 might regulate the attraction of T lymphocytes and dendritic cells in IBD.
Editor: Netherlands: Springer Nature B.V
Idioma: Inglês

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Increased expression of CCL20 in human inflammatory bowel disease

Kaser, Arthur ; Ludwiczek, Othmar ; Holzmann, Sandra ; Moschen, Alexander R ; Weiss, Günter ; Enrich, Barbara ; Graziadei, Ivo ; Dunzendorfer, Stefan ; Wiedermann, Christian J ; Mürzl, Elisabeth ; Grasl, Eveline ; Jasarevic, Zerina ; Romani, Nikolaus ; Offner, Felix A ; Tilg, Herbert

Netherlands: Springer Nature B.V

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