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A genome-wide resource of cell cycle and cell shape genes of fission yeast

Hayles, Jacqueline ; Wood, Valerie ; Jeffery, Linda ; Hoe, Kwang-Lae ; Kim, Dong-Uk ; Park, Han-Oh ; Salas-Pino, Silvia ; Heichinger, Christian ; Nurse, Paul

Open biology, 2013-05, Vol.3 (5), p.130053 [Periódico revisado por pares]

England: The Royal Society

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A genome-wide resource of cell cycle and cell shape genes of fission yeast
Autor: Hayles, Jacqueline ; Wood, Valerie ; Jeffery, Linda ; Hoe, Kwang-Lae ; Kim, Dong-Uk ; Park, Han-Oh ; Salas-Pino, Silvia ; Heichinger, Christian ; Nurse, Paul
Assuntos: Cell Cycle ; Cell Cycle - genetics ; Cell Shape ; Computational Biology ; Fission Yeast ; Gene Deletion ; Gene Expression Regulation, Fungal ; Genes, cdc ; Genes, Fungal ; Genome, Fungal ; Genome-Wide Gene Deletion Resource ; Humans ; Mutagenesis ; Phenotype ; Schizosaccharomyces - cytology ; Schizosaccharomyces - genetics ; Schizosaccharomyces pombe Proteins - genetics
É parte de: Open biology, 2013-05, Vol.3 (5), p.130053
Notas: These authors contributed equally to this study.
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Descrição: To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape.
Editor: England: The Royal Society
Idioma: Inglês

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A genome-wide resource of cell cycle and cell shape genes of fission yeast

Hayles, Jacqueline ; Wood, Valerie ; Jeffery, Linda ; Hoe, Kwang-Lae ; Kim, Dong-Uk ; Park, Han-Oh ; Salas-Pino, Silvia ; Heichinger, Christian ; Nurse, Paul

England: The Royal Society

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