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Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)

Biagioni, A F ; Silva, J A ; Coimbra, N C

Brazilian journal of medical and biological research, 2012-04, Vol.45 (4), p.328-336 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Medicina Tropical

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Título:
Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)
Autor: Biagioni, A F ; Silva, J A ; Coimbra, N C
Assuntos: Animals ; Anxiety ; Attention ; Bicuculline ; Bicuculline - pharmacology ; BIOLOGY ; Defensive behavior ; Dorsomedial Hypothalamic Nucleus - drug effects ; Dorsomedial Hypothalamic Nucleus - physiology ; Dorsomedial hypothalamus ; Escape behavior ; Escape Reaction - physiology ; Fear-induced antinociception ; Forebrain ; GABA-A Receptor Antagonists - pharmacology ; gamma -Aminobutyric acid ; gamma -Aminobutyric acid A receptors ; gamma -Aminobutyric acid receptors ; Hypothalamus ; Hypothalamus (dorsomedial) ; Hypothalamus, Posterior - drug effects ; Hypothalamus, Posterior - physiology ; Male ; Maze Learning ; MEDICINE, RESEARCH & EXPERIMENTAL ; Muridae ; Nuclei ; Pain perception ; Pain Threshold - drug effects ; Panic Disorder - etiology ; Panic Disorder - metabolism ; Panic-like behavior ; Posterior hypothalamus ; Rats ; Rattus norvegicus ; Rodentia ; Short Communication ; Sodium chloride
É parte de: Brazilian journal of medical and biological research, 2012-04, Vol.45 (4), p.328-336
Notas: ObjectType-Article-2
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Descrição: The hypothalamus is a forebrain structure critically involved in the organization of defensive responses to aversive stimuli. Gamma-aminobutyric acid (GABA)ergic dysfunction in dorsomedial and posterior hypothalamic nuclei is implicated in the origin of panic-like defensive behavior, as well as in pain modulation. The present study was conducted to test the difference between these two hypothalamic nuclei regarding defensive and antinociceptive mechanisms. Thus, the GABA(A) antagonist bicuculline (40 ng/0.2 µL) or saline (0.9% NaCl) was microinjected into the dorsomedial or posterior hypothalamus in independent groups. Innate fear-induced responses characterized by defensive attention, defensive immobility and elaborate escape behavior were evoked by hypothalamic blockade of GABA(A) receptors. Fear-induced defensive behavior organized by the posterior hypothalamus was more intense than that organized by dorsomedial hypothalamic nuclei. Escape behavior elicited by GABA(A) receptor blockade in both the dorsomedial and posterior hypothalamus was followed by an increase in nociceptive threshold. Interestingly, there was no difference in the intensity or in the duration of fear-induced antinociception shown by each hypothalamic division presently investigated. The present study showed that GABAergic dysfunction in nuclei of both the dorsomedial and posterior hypothalamus elicit panic attack-like defensive responses followed by fear-induced antinociception, although the innate fear-induced behavior originates differently in the posterior hypothalamus in comparison to the activity of medial hypothalamic subdivisions.
Editor: Brazil: Sociedade Brasileira de Medicina Tropical
Idioma: Inglês;Português

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Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)

Biagioni, A F ; Silva, J A ; Coimbra, N C

Brazil: Sociedade Brasileira de Medicina Tropical

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