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Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure

Brusasco, Claudia ; Corradi, Francesco ; Di Domenico, Antonia ; Raggi, Francesca ; Timossi, Graziano ; Santori, Gregorio ; Brusasco, Vito

The European respiratory journal, 2020, Vol.57 (2), p.2002524 [Peer Reviewed Journal]

England: European Respiratory Society

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Title:
Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure
Author: Brusasco, Claudia ; Corradi, Francesco ; Di Domenico, Antonia ; Raggi, Francesca ; Timossi, Graziano ; Santori, Gregorio ; Brusasco, Vito
Subjects: Adult ; Aged ; Aged, 80 and over ; Agora ; Air Filters ; Algorithms ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antirheumatic Agents - therapeutic use ; Comorbidity ; Continuous Positive Airway Pressure - methods ; COVID-19 - diagnostic imaging ; COVID-19 - drug therapy ; COVID-19 - epidemiology ; COVID-19 - physiopathology ; COVID-19 - therapy ; Diabetes Mellitus - epidemiology ; Female ; Glucocorticoids - therapeutic use ; Humans ; Hydroxychloroquine - therapeutic use ; Hypertension - epidemiology ; Hypoxia - physiopathology ; Hypoxia - therapy ; Interleukin 1 Receptor Antagonist Protein - therapeutic use ; Intubation, Intratracheal ; Lung - diagnostic imaging ; Male ; Methylprednisolone - therapeutic use ; Middle Aged ; Noninvasive Ventilation - methods ; Oxygen Inhalation Therapy ; Partial Pressure ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Respiratory Insufficiency - diagnostic imaging ; Respiratory Insufficiency - physiopathology ; Respiratory Insufficiency - therapy ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors ; Tomography, X-Ray Computed ; Treatment Failure ; Treatment Outcome
Is Part Of: The European respiratory journal, 2020, Vol.57 (2), p.2002524
Description: Noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) are recommended for acute hypoxaemic respiratory failure (AHRF) due to cardiogenic pulmonary oedema but no recommendation has been made for viral pandemics, because of the lack of randomised studies showing their efficacy and concerns of infection dissemination [1]. Early after the coronavirus disease 2019 (COVID-19) outbreak in Italy, there was an expert consensus in favour of CPAP and NIV as first-line treatments for the associated AHRF [2]. However, few studies used unspecified NIV in a minority of patients without detailed results [3–5]. CPAP was the object of two short reports with differing results [6, 7]. Thus, their value in COVID-19 remains to be established. CPAP can be successfully used in a number of COVID-19 patients with hypoxaemic respiratory failure and gas exchange and radiological findings similar to those generally considered to be indications for invasive mechanical ventilation https://bit.ly/2GpBx6a
Publisher: England: European Respiratory Society
Language: English

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Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure

Brusasco, Claudia ; Corradi, Francesco ; Di Domenico, Antonia ; Raggi, Francesca ; Timossi, Graziano ; Santori, Gregorio ; Brusasco, Vito

England: European Respiratory Society

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