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On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus

Tort, Adriano B.L ; Rotstein, Horacio G ; Dugladze, Tamar ; Gloveli, Tengis ; Kopell, Nancy J

Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (33), p.13490-13495 [Periódico revisado por pares]

United States: National Academy of Sciences

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  • Título:
    On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus
  • Autor: Tort, Adriano B.L ; Rotstein, Horacio G ; Dugladze, Tamar ; Gloveli, Tengis ; Kopell, Nancy J
  • Assuntos: Anatomy ; Animals ; Biological Sciences ; Brain ; Dendrites ; Hippocampus ; Hippocampus - cytology ; Histograms ; Interneurons ; Interneurons - cytology ; Mice ; Mice, Inbred C57BL ; Neurons ; Pyramidal cells ; Synapses ; Theta rhythm ; Torts
  • É parte de: Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (33), p.13490-13495
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Author contributions: H.G.R., T.G., and N.J.K. designed research; A.B.L.T. and T.D. performed research; A.B.L.T., H.G.R., and N.J.K. analyzed data; and A.B.L.T. and N.J.K. wrote the paper.
    Contributed by Nancy J. Kopell, June 19, 2007
  • Descrição: Gamma frequency (30-80 Hz) network oscillations have been observed in the hippocampus during several behavioral paradigms in which they are often modulated by a theta frequency (4-12 Hz) oscillation. Interneurons of the hippocampus have been shown to be crucially involved in rhythms generation, and several subtypes with distinct anatomy and physiology have been described. In particular, the oriens lacunosum-moleculare (O-LM) interneurons were shown to synapse on distal apical dendrites of pyramidal cells and to spike preferentially at theta frequency, even in the presence of gamma-field oscillations. O-LM cells have also recently been shown to present higher axonal ramification in the longitudinal axis of the hippocampus. By using a hippocampal network model composed of pyramidal cells and two types of interneurons (O-LM and basket cells), we show here that the O-LM interneurons lead to gamma coherence between anatomically distinct cell modules. We thus propose that this could be a mechanism for coupling longitudinally distant cells excited by entorhinal cortex inputs into gamma-coherent assemblies.
  • Editor: United States: National Academy of Sciences
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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