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The role of small diffusion-weighted imaging lesions in cerebral small vessel disease

Wiegertjes, Kim ; ter Telgte, Annemieke ; Oliveira, Pedro B ; van Leijsen, Esther M.C ; Bergkamp, Mayra I ; van Uden, Ingeborg W.M ; Ghafoorian, Mohsen ; van der Holst, Helena M ; Norris, David G ; Platel, Bram ; Klijn, Catharina J.M ; Tuladhar, Anil M ; de Leeuw, Frank-Erik

Neurology, 2019-10, Vol.93 (17), p.e1627-e1634 [Periódico revisado por pares]

United States: American Academy of Neurology

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  • Título:
    The role of small diffusion-weighted imaging lesions in cerebral small vessel disease
  • Autor: Wiegertjes, Kim ; ter Telgte, Annemieke ; Oliveira, Pedro B ; van Leijsen, Esther M.C ; Bergkamp, Mayra I ; van Uden, Ingeborg W.M ; Ghafoorian, Mohsen ; van der Holst, Helena M ; Norris, David G ; Platel, Bram ; Klijn, Catharina J.M ; Tuladhar, Anil M ; de Leeuw, Frank-Erik
  • Assuntos: Aged ; Aged, 80 and over ; Brain - diagnostic imaging ; Cerebral Small Vessel Diseases - diagnostic imaging ; Diffusion Magnetic Resonance Imaging ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies
  • É parte de: Neurology, 2019-10, Vol.93 (17), p.e1627-e1634
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: OBJECTIVETo investigate the prevalence of asymptomatic diffusion-weighted imaging–positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODSWe included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) study (mean age 65.6 years [SD 8.8], 56.5% male) with 1.5T MRI in 2006 and, if available, follow-up MRI in 2011 and 2015. We screened DWI scans (n = 1,152) for DWI+ lesions, assessed lesion evolution on follow-up fluid-attenuated inversion recovery, T1 and T2* images, and examined the association between DWI+ lesions and annual SVD progression (white matter hyperintensities [WMH], lacunes, microbleeds). RESULTSWe found 50 DWI+ lesions in 39 individuals on 1,152 DWI (3.4%). Individuals with DWI+ lesions were older (p = 0.025), more frequently had a history of hypertension (p = 0.021), and had a larger burden of preexisting SVD MRI markers (WMH, lacunes, microbleedsall p < 0.001) compared to individuals without DWI+ lesions. Of the 23 DWI+ lesions with available follow-up MRI, 14 (61%) evolved into a WMH, 8 (35%) resulted in a cavity, and 1 (4%) was no longer visible. Presence of DWI+ lesions was significantly associated with annual WMH volume increase and yearly incidence of lacunes and microbleeds (all p < 0.001). CONCLUSIONOver 3% of individuals with SVD have DWI+ lesions. Although DWI+ lesions play a role in the progression of SVD, they may not fully explain progression of SVD markers on MRI, suggesting that other factors than acute ischemia are at play.
  • Editor: United States: American Academy of Neurology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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