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Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

Maia, Cristiane ; Pinheiro, Bruno Gonçalves ; Soares da Silva, Carla Cristiane ; Cunha, Rodrigo A. ; Souza-Monteiro, Deiweson ; Martins Ferreira, Maria Karolina ; Schmidt, Tuany Rafaeli ; de Souza Balbinot, Gabriela ; Collares, Fabrício Mezzomo ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues

Biomedicine & pharmacotherapy, 2020-10, Vol.130 (C), p.110608, Article 110608 [Periódico revisado por pares]

France: Elsevier Masson SAS

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Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats
Autor: Maia, Cristiane ; Pinheiro, Bruno Gonçalves ; Soares da Silva, Carla Cristiane ; Cunha, Rodrigo A. ; Souza-Monteiro, Deiweson ; Martins Ferreira, Maria Karolina ; Schmidt, Tuany Rafaeli ; de Souza Balbinot, Gabriela ; Collares, Fabrício Mezzomo ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues
Assuntos: Adenosine A2 Receptor Antagonists - pharmacology ; Adenosine A2A receptor ; Adolescence ; Alveolar bone loss ; Alveolar Bone Loss - etiology ; Alveolar Bone Loss - pathology ; Alveolar Bone Loss - prevention & control ; Animals ; Binge drinking ; Binge Drinking - complications ; Bone Density - drug effects ; Caffeine ; Caffeine - pharmacology ; Ethanol - pharmacology ; Female ; Neuroprotective Agents - pharmacology ; Periodontitis ; Periodontitis - etiology ; Periodontitis - prevention & control ; Pyrimidines - pharmacology ; Rats ; Rats, Wistar ; Triazoles - pharmacology ; X-Ray Microtomography
É parte de: Biomedicine & pharmacotherapy, 2020-10, Vol.130 (C), p.110608, Article 110608
Notas: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Fuel Cell Technologies Office
POCI-01-0145-FEDER-03127
Descrição: [Display omitted] •Adolescent ethanol binge intake induces alveolar bone damage.•Caffeine preserves alveolar bone injury caused by ethanol.•This effect of caffeine is not mediated by A2A receptors. Ethanol consumption has been reported to negatively impact on periodontal disease. In particular, oral cavity disorders occur upon ethanol exposure during adolescence, a life period associated with particular patterns of short and intense (‘binge-like’) ethanol consumption that is most deleterious to oral health. The hazardous central effects of ethanol have been linked to the overfunction of adenosine receptors, which are antagonized by caffeine, a bioactive substance present in numerous natural nutrients, which can also modify bone metabolism. The aim of this study was to investigate the effects of caffeine on alveolar bone damage induced by an ethanol binge drinking paradigm during adolescence. Female Wistar rats (35 days old; n = 30) were allocated to six groups: control (vehicle), ethanol (3 g/kg/day; 3 days On-4 days Off challenge), caffeine (10 mg/kg/day), caffeine plus ethanol, SCH58261 (0.1 mg/kg/day, an antagonist of A2A receptors), and SCH58261 plus ethanol. Bone micromorphology and vertical bone loss were analyzed by computed microtomography. Our data showed that ethanol binge drinking reduced alveolar bone quality, with repercussion on alveolar bone size. This ethanol-induced alveolar bone deterioration was abrogated upon treatment with caffeine, but not with SCH58261. This shows that caffeine prevented the periodontal disorder caused by ethanol binge drinking during adolescence, an effect that was not mediated by adenosine A2A receptor blockade.
Editor: France: Elsevier Masson SAS
Idioma: Inglês

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Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

France: Elsevier Masson SAS

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