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Obesity and risk of sepsis: A population‐based cohort study

Wang, Henry E. ; Griffin, Russell ; Judd, Suzanne ; Shapiro, Nathan I ; Safford, Monika M.

Obesity (Silver Spring, Md.), 2013-12, Vol.21 (12), p.E762-E769 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    Obesity and risk of sepsis: A population‐based cohort study
  • Autor: Wang, Henry E. ; Griffin, Russell ; Judd, Suzanne ; Shapiro, Nathan I ; Safford, Monika M.
  • Assuntos: Aged ; Body Composition ; Body Mass Index ; C-Reactive Protein - metabolism ; Female ; Hospitalization ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Mortality ; Obesity ; Obesity, Morbid - complications ; Obesity, Morbid - pathology ; Risk Factors ; Sepsis - complications ; Sepsis - epidemiology ; Socioeconomic Factors ; Waist Circumference ; Waist-Hip Ratio ; Weight control
  • É parte de: Obesity (Silver Spring, Md.), 2013-12, Vol.21 (12), p.E762-E769
  • Notas: This research project is supported by a cooperative agreement U01‐NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Representatives of the funding agency have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data. Additional funding was provided by R01‐NR012726 from the National Institute for Nursing Research, UL1‐RR025777 from the National Center for Research Resources, as well as by grants from the Center for Clinical and Translational Science and the Lister Hill Center for Health Policy of the University of Alabama at Birmingham. Representatives from these organizations did not have any role in the design and conduct of the study, the collection, management, analysis, and interpretation of the data, or the preparation or approval of the manuscript.
    HEW, NIS, and MMS conceived the study. RG performed the analysis. All authors contributed to the critical review of analytic results. HEW drafted the manuscript, and all authors contributed substantially to its critical revision and final approval.
    Disclosure
    None reported. The authors declare no competing interests.
    Funding agencies
    Author contributions
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Objective Sepsis, the syndrome of microbial infection complicated by systemic inflammation, is associated with significant morbidity and mortality. To determine if obesity increases risk of sepsis events. Design and Methods Data from the 30,239 subject population‐based longitudinal cohort study REasons for Geographic and Racial Differences in Stroke (REGARDS) were used. Using measurements at the start of the study, we defined obesity using body mass index (BMI; <18.5 kg/m2 = underweight, 18.5‐24.9 = normal, 25.0‐29.9 = overweight, 30.0‐39.9 = obese, ≥40 = morbidly obese) and waist circumference (WC; [male ≤102 cm or female ≤88 cm] = normal, [male >102 cm or female >88 cm] = obese). Over an 8‐year observation period, we evaluated the association between obesity and subsequent sepsis events, adjusting for sociodemographic factors, health behaviors, chronic medical conditions, statin use, and high‐sensitivity C‐reactive protein. Results There were 975 incident sepsis events. Compared to those with a BMI of 18.5‐24.9, sepsis risk was higher only for BMI ≥ 40 (hazard ratio [HR] 1.57, [1.16‐2.14]). Risk of sepsis was associated with increased WC (HR 1.34 [1.14‐1.56]). In a model with both BMI and WC, sepsis risk was associated with increased WC (HR 1.47 [1.20‐1.79]) but not BMI. Conclusions Obesity is independently associated with future sepsis events. WC is a better predictor of future sepsis risk than BMI.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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