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Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network

Sehouli, Jalid ; Braicu, Elena Ioana ; Richter, Rolf ; Denkert, Carsten ; Jank, Paul ; Jurmeister, Philipp Sebastian ; Kunze, Catarina Alisa ; Budczies, Jan ; Darb-Esfahani, Sylvia ; Schmitt, Wolfgang Daniel ; Traut, Alexander ; Grabowski, Jacek ; Taube, Eliane Tabea ; Plett, Helmut

Human pathology, 2019-03, Vol.85, p.299-308 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network
  • Autor: Sehouli, Jalid ; Braicu, Elena Ioana ; Richter, Rolf ; Denkert, Carsten ; Jank, Paul ; Jurmeister, Philipp Sebastian ; Kunze, Catarina Alisa ; Budczies, Jan ; Darb-Esfahani, Sylvia ; Schmitt, Wolfgang Daniel ; Traut, Alexander ; Grabowski, Jacek ; Taube, Eliane Tabea ; Plett, Helmut
  • Assuntos: Age ; Breast cancer ; Cancer therapies ; Cell cycle ; Cell division ; Chemotherapy ; Cloning ; Hormone receptor ; Ki-67 ; Low-grade serous ovarian carcinoma ; Mutation ; Ovarian cancer ; Prognostic marker ; Proliferative activity ; Studies ; Tumors
  • É parte de: Human pathology, 2019-03, Vol.85, p.299-308
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Low-grade serous ovarian carcinoma (LGSOC) has recently come up as a distinct rare entity of epithelial ovarian cancer. Predictive and prognostic markers are not well studied yet. Because Ki-67 and hormone receptors (HR) have been established as relevant cancer biomarkers in several malignant tumors, we evaluated Ki-67 and HR expression rates by immunohistochemistry in 68 patients with LGSOC. We used a standardized cutoff finder algorithm to analyze prognostic significance for overall survival (OS) and progression-free survival (PFS). Cox regression showed a significant continuous decrease in OS for higher proliferation rates with an HR  of 1.07% (95% confidence interval, 1.01%-3.67%; P = .048) but not in PFS (P = .86). Cutoff finder analysis revealed the best possible cutoff for OS at 6.28% (P = .04) and for PFS at 1.85% proliferative activity (P = .04). Estrogen receptors (ERs) were expressed in most LGSOC patients (n = 61; 89.7%), progesterone receptor (PR) in about half of patients (n = 33; 48.5%). For both ER/PR, a statistically significant cutoff for PFS could be determined, which was at 75% of positive tumor cells for ER (P = .02) and at 15% of positive tumor cells for PR (P = .03). For OS, HR expression showed a tendency toward better OS for HR-positive tumors but did not turn out statistically significant. Our results show that Ki-67 is a valuable prognostic marker in the subgroup of LGSOC. We could also show that most LGSOCs express HRs but that this expression is associated with a better PFS, a finding valuable in times of antihormonal therapy in LGSOC. •Ki-67 is an independent prognostic factor for low-grade serous ovarian carcinoma.•Low-grade serous ovarian carcinomas show strong positivity for estrogen receptor.•Low-grade serous ovarian carcinomas show moderate positivity for progesterone receptor.•High hormone receptor expression correlates with a better progression-free survival.•Hormone receptor expression shows only a tendency toward a better overall survival.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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