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Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats

Schimming, Bruno Cesar ; Cirino, Mucio Luiz de Assis ; Lizarte Neto, Fermino Sanches ; Novais, Paulo Cezar ; Carvalho, Camila Albuquerque Melo de ; Tirapelli, Daniela Pretti da Cunha ; Molina, Carlos Augusto Fernandes ; Tirapelli, Luis Fernando ; Tucci Junior, Silvio

Acta cirúrgica brasileira, 2020-01, Vol.35 (8) [Periódico revisado por pares]

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia

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  • Título:
    Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats
  • Autor: Schimming, Bruno Cesar ; Cirino, Mucio Luiz de Assis ; Lizarte Neto, Fermino Sanches ; Novais, Paulo Cezar ; Carvalho, Camila Albuquerque Melo de ; Tirapelli, Daniela Pretti da Cunha ; Molina, Carlos Augusto Fernandes ; Tirapelli, Luis Fernando ; Tucci Junior, Silvio
  • Assuntos: Caspases ; Diabetes Mellitus ; Ethanol ; Rats
  • É parte de: Acta cirúrgica brasileira, 2020-01, Vol.35 (8)
  • Descrição: Abstract Purpose To evaluate the effects of alcohol exposure and diabetes on apoptotic process in the corpus cavernosum. Methods Forty eight male Wistar rats were divided into four groups: control, diabetic, alcoholic and diabetic-alcoholic. Samples of the corpus cavernosum were prepared to study protein expression of apoptotic genes (Caspases-3 and 9) by immunohistochemistry and Real-Time PCR. Results The immunoreactivity of Caspases-3 and -9 was diffuse and higher in the treated groups though there was no significant difference between the experimental groups, only when compared with the control group. An increase was observed in the gene expression of Caspases-9 in the diabetic and ethanol-diabetic groups when compared with control and ethanol groups. Conclusions The association of these factors (ethanol and diabetes) probably can affect the apoptosis mechanism in lesions of the cavernous tissue in the rat penis. Both gene and protein expression of Caspase-9 in diabetic and ethanol-diabetic groups suggest the involvement of the apoptosis cascade from this study model.
  • Editor: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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