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Higher Accumulation of Docosahexaenoic Acid in the Vermilion of the Human Lip than in the Skin

Mamun, Md Al ; Sato, Shumpei ; Naru, Eiji ; Sakata, Osamu ; Hoshikawa, Emi ; Suzuki, Ayako ; Islam, Ariful ; Kahyo, Tomoaki ; Sato, Tomohito ; Ito, Takashi K ; Horikawa, Makoto ; Fukui, Reimu ; Izumi, Kenji ; Setou, Mitsutoshi

International journal of molecular sciences, 2020-04, Vol.21 (8), p.2807 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Higher Accumulation of Docosahexaenoic Acid in the Vermilion of the Human Lip than in the Skin
Autor: Mamun, Md Al ; Sato, Shumpei ; Naru, Eiji ; Sakata, Osamu ; Hoshikawa, Emi ; Suzuki, Ayako ; Islam, Ariful ; Kahyo, Tomoaki ; Sato, Tomohito ; Ito, Takashi K ; Horikawa, Makoto ; Fukui, Reimu ; Izumi, Kenji ; Setou, Mitsutoshi
Assuntos: Accumulation ; Aging ; Antioxidants ; Arachidonic acid ; Arachidonic Acid - analysis ; Cosmetics ; DESI–MSI ; Docosahexaenoic acid ; Docosahexaenoic Acids - analysis ; Epithelium ; Fatty acids ; Fatty Acids, Monounsaturated - analysis ; Female ; free fatty acids ; human lip ; Humans ; Infant ; Linoleic acid ; Linoleic Acid - analysis ; Lip ; Lip - chemistry ; Lip - surgery ; Male ; Mass Spectrometry ; Mass spectroscopy ; Mucosa ; Oleic acid ; Oleic Acid - analysis ; Palmitoleic acid ; Scientific imaging ; Skin ; Skin - chemistry ; Spectrometry, Mass, Electrospray Ionization ; Spectroscopy ; Tissue Distribution ; vermilion
É parte de: International journal of molecular sciences, 2020-04, Vol.21 (8), p.2807
Descrição: The vermilion of the human lip is a unique facial area because of certain distinguishing features from the adjacent tissues such as the white lip (skin) and oral mucosa. However, the distinction in terms of molecular distribution between the vermilion and skin has remained unexplored. Therefore, we aimed to map the human lip by mass spectrometry imaging to gain understanding of the free fatty acid distribution in the vermilion. The lip specimens trimmed off during cheiloplasty were analyzed using desorption electrospray ionization-mass spectrometry imaging. Distributions of two monounsaturated fatty acids and three polyunsaturated fatty acids were observed in the human lip tissue: palmitoleic acid (POA) and oleic acid (OA) and linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA), respectively. Although POA, OA, LA, and AA were differentially distributed across the vermilion and skin, DHA showed a higher accumulation in the epithelium of the vermilion compared to that in the skin. Our results clearly demonstrated the difference in fatty acid distributions between the vermilion and skin. The highly abundant DHA in the epithelium of the vermilion may have an antioxidant role and may thus protect the lip from aging. Our findings can provide a novel strategy for treating lip disorders.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Higher Accumulation of Docosahexaenoic Acid in the Vermilion of the Human Lip than in the Skin

Mamun, Md Al ; Sato, Shumpei ; Naru, Eiji ; Sakata, Osamu ; Hoshikawa, Emi ; Suzuki, Ayako ; Islam, Ariful ; Kahyo, Tomoaki ; Sato, Tomohito ; Ito, Takashi K ; Horikawa, Makoto ; Fukui, Reimu ; Izumi, Kenji ; Setou, Mitsutoshi

Switzerland: MDPI AG

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