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Antitumor Activity of Biflorin, an o-Naphthoquinone Isolated from Capraria biflora

Vasconcellos, Marne Carvalho de ; Bezerra, Daniel Pereira ; Fonseca, Aluísio Marques ; Pereira, Márcio Roberto Pinho ; Lemos, Telma Leda Gomes ; Pessoa, Otília Deusdênia Loiola ; Pessoa, Cláudia ; Moraes, Manoel Odorico de ; Ana Paula Negreiros Nunes Alves ; Costa-Lotufo, Letícia Veras

Biological and Pharmaceutical Bulletin, 2007/08/01, Vol.30(8), pp.1416-1421 [Periódico revisado por pares]

Japan: The Pharmaceutical Society of Japan

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Título:
Antitumor Activity of Biflorin, an o-Naphthoquinone Isolated from Capraria biflora
Autor: Vasconcellos, Marne Carvalho de ; Bezerra, Daniel Pereira ; Fonseca, Aluísio Marques ; Pereira, Márcio Roberto Pinho ; Lemos, Telma Leda Gomes ; Pessoa, Otília Deusdênia Loiola ; Pessoa, Cláudia ; Moraes, Manoel Odorico de ; Ana Paula Negreiros Nunes Alves ; Costa-Lotufo, Letícia Veras
Assuntos: Adjuvants, Immunologic - pharmacology ; Animals ; Antimetabolites, Antineoplastic - therapeutic use ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; antitumor activity ; biflorin ; Capraria biflora ; Carcinoma, Ehrlich Tumor - drug therapy ; Carcinoma, Ehrlich Tumor - pathology ; Ehrlich carcinoma ; Female ; Fluorouracil - therapeutic use ; Immunohistochemistry ; Indicators and Reagents ; Ki-67 Antigen - metabolism ; Mice ; Naphthoquinones - pharmacology ; Neoplasm Transplantation ; Ovalbumin - immunology ; sarcoma 180 ; Sarcoma 180 - drug therapy ; Sarcoma 180 - pathology ; Scrophulariaceae - chemistry
É parte de: Biological and Pharmaceutical Bulletin, 2007/08/01, Vol.30(8), pp.1416-1421
Descrição: Pharmacological studies with an aqueous extract obtained from leaves of Capraria biflora showed potent cytotoxic, analgesic, antimicrobial and anti-inflammatory activities. It has been demonstrated that biflorin possesses an in vitro cytotoxic activity against tumor cells. The in vivo antitumor activity of biflorin was evaluated on two mouse models, sarcoma 180 and Ehrlich carcinoma. Biflorin was active against both tumors with a very similar profile. In addition, biflorin was also able to increase the response elicited by 5-FU in mice inoculated with both tumors. The results showed a decrease in Ki67 staining in tumor cells from treated-animals when compared with non-treated groups, which suggests an inhibition of tumor proliferation rate. Histopathological analysis from kidneys and liver showed that biflorin possessed weak and reversible toxic effects. It was also demonstrated that biflorin acts as an immunoadjuvant agent, rising the production of ovalbumin-specific antibodies and inducing a discreet increase of the white pulp and nest of megakaryocytic in spleen of treated mice, which can be related to its antitumor properties.
Editor: Japan: The Pharmaceutical Society of Japan
Idioma: Inglês;Japonês

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Antitumor Activity of Biflorin, an o-Naphthoquinone Isolated from Capraria biflora

Vasconcellos, Marne Carvalho de ; Bezerra, Daniel Pereira ; Fonseca, Aluísio Marques ; Pereira, Márcio Roberto Pinho ; Lemos, Telma Leda Gomes ; Pessoa, Otília Deusdênia Loiola ; Pessoa, Cláudia ; Moraes, Manoel Odorico de ; Ana Paula Negreiros Nunes Alves ; Costa-Lotufo, Letícia Veras

Japan: The Pharmaceutical Society of Japan

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