Idioma:

Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium

Sujana, Chaterina ; Salomaa, Veikko ; Kee, Frank ; Seissler, Jochen ; Jousilahti, Pekka ; Neville, Charlotte ; Then, Cornelia ; Koenig, Wolfgang ; Kuulasmaa, Kari ; Reinikainen, Jaakko ; Blankenberg, Stefan ; Zeller, Tanja ; Herder, Christian ; Mansmann, Ulrich ; Peters, Annette ; Thorand, Barbara

Cardiovascular Diabetology, 2022-06, Vol.21 (1), p.99-10, Article 99 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium
Autor: Sujana, Chaterina ; Salomaa, Veikko ; Kee, Frank ; Seissler, Jochen ; Jousilahti, Pekka ; Neville, Charlotte ; Then, Cornelia ; Koenig, Wolfgang ; Kuulasmaa, Kari ; Reinikainen, Jaakko ; Blankenberg, Stefan ; Zeller, Tanja ; Herder, Christian ; Mansmann, Ulrich ; Peters, Annette ; Thorand, Barbara
Assuntos: Adipocytes ; Adrenomedullin ; Analysis ; Antihypertensives ; Biomarkers ; Blood pressure ; Body composition ; Body mass index ; C-terminal-proendothelin-1 ; Cardiovascular diseases ; Cohort analysis ; Consortia ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Endothelin ; Endothelin 1 ; Epidemiology ; Glucose metabolism ; Heart Disease Risk Factors ; Homeostasis ; Humans ; Hypertension ; Incident type 2 diabetes ; Insulin resistance ; Laboratories ; Life Sciences ; Mendelian randomisation ; Metabolism ; Obesity ; Pathogenesis ; Peptide Fragments ; Peptides ; Physiological aspects ; Prospective Studies ; Protein Precursors ; Risk assessment ; Vasoactive agents ; Womens health
É parte de: Cardiovascular Diabetology, 2022-06, Vol.21 (1), p.99-10, Article 99
Descrição: Endothelin-1 (ET-1) and adrenomedullin (ADM) are commonly known as vasoactive peptides that regulate vascular homeostasis. Less recognised is the fact that both peptides could affect glucose metabolism. Here, we investigated whether ET-1 and ADM, measured as C-terminal-proET-1 (CT-proET-1) and mid-regional-proADM (MR-proADM), respectively, were associated with incident type 2 diabetes. Based on the population-based Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium data, we performed a prospective cohort study to examine associations of CT-proET-1 and MR-proADM with incident type 2 diabetes in 12,006 participants. During a median follow-up time of 13.8 years, 862 participants developed type 2 diabetes. The associations were examined in Cox proportional hazard models. Additionally, we performed two-sample Mendelian randomisation analyses using published data. CT-proET-1 and MR-proADM were positively associated with incident type 2 diabetes. The multivariable hazard ratios (HRs) [95% confidence intervals (CI)] were 1.10 [1.03; 1.18], P = 0.008 per 1-SD increase of CT-proET-1 and 1.11 [1.02; 1.21], P = 0.016 per 1-SD increase of log MR-proADM, respectively. We observed a stronger association of MR-proADM with incident type 2 diabetes in obese than in non-obese individuals (P-interaction with BMI < 0.001). The HRs [95%CIs] were 1.19 [1.05; 1.34], P = 0.005 and 1.02 [0.90; 1.15], P = 0.741 in obese and non-obese individuals, respectively. Our Mendelian randomisation analyses yielded a significant association of CT-proET-1, but not of MR-proADM with type 2 diabetes risk. Higher concentrations of CT-proET-1 and MR-proADM are associated with incident type 2 diabetes, but our Mendelian randomisation analysis suggests a probable causal link for CT-proET-1 only. The association of MR-proADM seems to be modified by body composition.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium

Sujana, Chaterina ; Salomaa, Veikko ; Kee, Frank ; Seissler, Jochen ; Jousilahti, Pekka ; Neville, Charlotte ; Then, Cornelia ; Koenig, Wolfgang ; Kuulasmaa, Kari ; Reinikainen, Jaakko ; Blankenberg, Stefan ; Zeller, Tanja ; Herder, Christian ; Mansmann, Ulrich ; Peters, Annette ; Thorand, Barbara

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.