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Rhabdomyolysis in patients treated by corticosteroids for acute asthma in intensive care unit

Abad, S ; Bonnet, N ; Bouvry, D ; Cohen, Y ; Dhote, R

La revue de medecine interne, 2019-04, Vol.40 (4), p.255-257 [Periódico revisado por pares]

France

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Título:
Rhabdomyolysis in patients treated by corticosteroids for acute asthma in intensive care unit
Autor: Abad, S ; Bonnet, N ; Bouvry, D ; Cohen, Y ; Dhote, R
Assuntos: Acute Disease ; Adrenal Cortex Hormones - adverse effects ; Adrenal Cortex Hormones - therapeutic use ; Asthma - drug therapy ; Asthma - pathology ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Middle Aged ; Rhabdomyolysis - chemically induced ; Rhabdomyolysis - diagnosis ; Severity of Illness Index
É parte de: La revue de medecine interne, 2019-04, Vol.40 (4), p.255-257
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
Descrição: Acute muscle involvement is an infrequent complication of corticosteroids, characterized by muscle weakness and a rhabdomyolysis, rapidly regressive after withdrawal of corticosteroids. We report the case of a woman admitted in intensive care unit for acute severe asthma, treated with high doses of methylprednisolone. Serum CPK level raised with a peak at 28,160 UI/L (n<250 UI/L) at day 15, suggesting acute rhabdomyolysis with renal failure. CPK rapidly normalized when corticosteroids were discontinued. Other causes of rhabdomyolysis were ruled out. This necrosing myopathy under high doses of corticosteroids has been described in patients with severe acute asthma. The mechanism of the muscle damage results from a combination of corticosteroids toxicity, respiratory acidosis and mechanic ventilation.
Editor: France
Idioma: Francês

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Rhabdomyolysis in patients treated by corticosteroids for acute asthma in intensive care unit

Abad, S ; Bonnet, N ; Bouvry, D ; Cohen, Y ; Dhote, R

France

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