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Transgenerational epigenetic imprints on mate preference

Crews, David ; Gore, Andrea C ; Hsu, Timothy S ; Dangleben, Nygerma L ; Spinetta, Michael ; Schallert, Timothy ; Anway, Matthew D ; Skinner, Michael K

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (14), p.5942-5946 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Transgenerational epigenetic imprints on mate preference
Autor: Crews, David ; Gore, Andrea C ; Hsu, Timothy S ; Dangleben, Nygerma L ; Spinetta, Michael ; Schallert, Timothy ; Anway, Matthew D ; Skinner, Michael K
Assuntos: Androgen Antagonists - pharmacology ; Animal reproduction ; Animals ; Biological Sciences ; Breeding of animals ; Cellular biology ; Deoxyribonucleic acid ; Discriminant analysis ; DNA ; Endocrine Disruptors - pharmacology ; Epigenesis, Genetic - drug effects ; Epigenesis, Genetic - genetics ; Epigenetics ; Female ; Female animals ; Gender discrimination ; Genomic Imprinting - drug effects ; Genomic Imprinting - genetics ; Laboratory animals ; Male ; Male animals ; Mating behavior ; Mating Preference, Animal - drug effects ; Mental stimulation ; Odors ; Oxazoles - pharmacology ; Pesticides ; Phenotypes ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats ; Rats, Sprague-Dawley ; Side effects
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (14), p.5942-5946
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: D.C. and A.C.G. contributed equally to this work; D.C. and A.C.G. designed research; A.C.G., T.S.H., N.L.D., and M.S. performed research; T.S., M.D.A., and M.K.S. contributed new reagents/analytic tools; D.C., T.S.H., and M.S. analyzed data; and D.C., A.C.G., M.S., T.S., and M.K.S. wrote the paper.
Edited by Bruce S. McEwen, The Rockefeller University, New York, NY, and approved February 14, 2007
Descrição: Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease across subsequent generations. In natural populations, both sexes may encounter affected as well as unaffected individuals during the breeding season, and any diminution in attractiveness could compromise reproductive success. Here we examine mate preference in male and female rats whose progenitors had been treated with the antiandrogenic fungicide vinclozolin. This effect is sex-specific, and we demonstrate that females three generations removed from the exposure discriminate and prefer males who do not have a history of exposure, whereas similarly epigenetically imprinted males do not exhibit such a preference. The observations suggest that the consequences of EDCs are not just transgenerational but can be "transpopulational", because in many mammalian species, males are the dispersing sex. This result indicates that epigenetic transgenerational inheritance of EDC action represents an unappreciated force in sexual selection. Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Transgenerational epigenetic imprints on mate preference

Crews, David ; Gore, Andrea C ; Hsu, Timothy S ; Dangleben, Nygerma L ; Spinetta, Michael ; Schallert, Timothy ; Anway, Matthew D ; Skinner, Michael K

United States: National Academy of Sciences

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