Idioma:

Investigation of the Anticancer and Drug Combination Potential of Brominated Coelenteramines toward Breast and Prostate Cancer

Magalhães, Carla M ; González-Berdullas, Patricia ; Pereira, Mariana ; Duarte, Diana ; Vale, Nuno ; Esteves da Silva, Joaquim C G ; Pinto da Silva, Luís

International journal of molecular sciences, 2022-11, Vol.23 (22), p.13981 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
Investigation of the Anticancer and Drug Combination Potential of Brominated Coelenteramines toward Breast and Prostate Cancer
Autor: Magalhães, Carla M ; González-Berdullas, Patricia ; Pereira, Mariana ; Duarte, Diana ; Vale, Nuno ; Esteves da Silva, Joaquim C G ; Pinto da Silva, Luís
Assuntos: Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Antitumor activity ; Bioluminescence ; Breast cancer ; Bromination ; Cancer therapies ; cancer therapy ; chemiluminescence ; Chemotherapy ; coelenteramine ; coelenterazine ; Cytotoxicity ; Decomposition ; drug combination ; Drug Combinations ; Gastric cancer ; Humans ; Investigations ; Lung cancer ; Male ; Marine chemistry ; Molecular Structure ; Prostate ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Spectrum analysis ; Structure-Activity Relationship
É parte de: International journal of molecular sciences, 2022-11, Vol.23 (22), p.13981
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Cancer is a very challenging disease to treat, both in terms of therapeutic efficiency and harmful side effects, which continues to motivate the pursuit for novel molecules with potential anticancer activity. Herein, we have designed, synthesized, and evaluated the cytotoxicity of different brominated coelenteramines, which are metabolic products and synthesis precursors of the chemi-/bioluminescent system of marine coelenterazine. The evaluation of the anticancer potential of these molecules was carried out for both prostate and breast cancer, while also exploring their potential for use in combination therapy. Our results provided further insight into the structure-activity relationship of this type of molecule, such as their high structural specificity, as well highlighting the 4-bromophenyl moiety as essential for the anticancer activity. The obtained data also indicated that, despite their similarity, the anticancer activity displayed by both brominated coelenteramines and coelenterazines should arise from independent mechanisms of action. Finally, one of the studied coelenteramines was able to improve the profile of a known chemotherapeutic agent, even at concentrations in which its anticancer activity was not relevant. Thus, our work showed the potential of different components of marine chemi-/bioluminescent systems as novel anticancer molecules, while providing useful information for future optimizations.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Investigation of the Anticancer and Drug Combination Potential of Brominated Coelenteramines toward Breast and Prostate Cancer

Magalhães, Carla M ; González-Berdullas, Patricia ; Pereira, Mariana ; Duarte, Diana ; Vale, Nuno ; Esteves da Silva, Joaquim C G ; Pinto da Silva, Luís

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.