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Secrets of Endometrial Receptivity: Some Are Hidden in Uterine Secretome

Bhusane, Kashmira ; Bhutada, Sumit ; Chaudhari, Uddhav ; Savardekar, Lalita ; Katkam, Rajendra ; Sachdeva, Geetanjali

American journal of reproductive immunology (1989), 2016-03, Vol.75 (3), p.226-236 [Periódico revisado por pares]

Denmark: Blackwell Publishing Ltd

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  • Título:
    Secrets of Endometrial Receptivity: Some Are Hidden in Uterine Secretome
  • Autor: Bhusane, Kashmira ; Bhutada, Sumit ; Chaudhari, Uddhav ; Savardekar, Lalita ; Katkam, Rajendra ; Sachdeva, Geetanjali
  • Assuntos: Animals ; Body Fluid Compartments - immunology ; Body Fluid Compartments - metabolism ; Embryo, Mammalian - cytology ; Embryo, Mammalian - immunology ; Embryo, Mammalian - metabolism ; Embryonic Development - physiology ; Endometrium ; Endometrium - cytology ; Endometrium - immunology ; Endometrium - secretion ; Fallopian Tubes - cytology ; Fallopian Tubes - immunology ; Fallopian Tubes - secretion ; Female ; Humans ; Pregnancy - immunology ; Pregnancy - metabolism ; proteome ; receptivity ; uterine fluid
  • É parte de: American journal of reproductive immunology (1989), 2016-03, Vol.75 (3), p.226-236
  • Notas: ArticleID:AJI12472
    Indian Council of Medical Research
    ark:/67375/WNG-WDW140ZK-7
    istex:803BEF12C6FDED447B11A83DF3D3DB65C8575A73
    Department of Biotechnology, Government of India
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    ObjectType-Article-1
    ObjectType-Feature-2
  • Descrição: Problem Endometrium, the innermost mucosal layer of the uterus, serves as a lodge for the embryo in eutherian mammals. The endometrium is constituted of various cell types, and each cell type executes specific functions to facilitate embryo implantation and development. It is well established that the endometrium, despite being non‐permissive to the embryo for the major period of a menstrual cycle, is irreplaceable in the scheme of events essential for procreation. However, the embryo, before initiating physical contact with the endometrium, encounters the uterine cavity that remains bathed in uterine fluid. Uterine fluid is an admixture of endometrial secretions, plasma transudates, and oviductal fluid. Uterine fluid components are believed to play important roles in immunosuppression and embryo development during peri‐implantation period. Uterine fluid is also involved in defense against pathogens, sperm migration, and lubrication of endometrium. The advent of high‐throughput functional genomics tools has created enormous opportunities to investigate the uterine fluid for its protein repertoire and modulation during the receptive phase of an endometrial cycle in animals and humans. Towards this, few investigations have been conducted in recent years. The data obtained using non‐targetted functional genomics approaches need to be assimilated with the existing information on specific components of uterine fluid. Method This review compiles existing information on the composition of uterine fluid and its significance in endometrial functions and dysfunctions. Result Collectively, investigations based on targetted and non‐targetted approaches have revealed the presence of several cytokines, growth factors, ions, carbohydrates, and steroids, in human uterine fluid. Conclusion Detailed investigations of human uterine fluid, especially directed towards the elucidation of functional relevance of different proteins in uterine fluid, will help identify novel markers of endometrial receptivity and also gain significant insights into the mechanisms underlying unexplained infertility, recurrent pregnancy losses, and other endometrial pathologies.
  • Editor: Denmark: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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