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Concerning the Mechanism of Anaphylactic and Tryptic Shock

Rocha E Silva, M

The Journal of immunology (1950), 1941-04, Vol.40 (4), p.399-404 [Periódico revisado por pares]

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Título:
Concerning the Mechanism of Anaphylactic and Tryptic Shock
Autor: Rocha E Silva, M
É parte de: The Journal of immunology (1950), 1941-04, Vol.40 (4), p.399-404
Descrição: Abstract Recently, we have described the effects produced by trypsin upon the mammalian smooth muscles (guinea-pig intestine, guinea-pig uterus, rabbit, cat and dog intestines, virgin uterus of the rat and mouse intestines (1–3)), as well as the circulatory effects produced in rabbits, cats and dogs by trypsin injected intravenously (2, 4). In experiments of perfusion of guinea-pig lungs we have demonstrated the ability of trypsin to liberate histamine from the tissues, and suggested that this may offer a basis for understanding the pharmacological effects of trypsin (4). The constancy of the phenomenon of “desensitization” observed on repeated additions of the same small dose of trypsin strongly suggested that the action of trypsin was an indirect one, probably through the intermediary of a tissular active substance—histamine—set free under the action of the ferment.
Editor: Am Assoc Immnol
Idioma: Inglês

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