skip to main content
Idioma:

Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases

Tucci, Frank J. ; Rosenzweig, Amy C.

Chemical reviews, 2024-02, Vol.124 (3), p.1288-1320 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
  • Título:
    Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases
  • Autor: Tucci, Frank J. ; Rosenzweig, Amy C.
  • Assuntos: Biology ; Catalysis ; Catalysts ; Climate change ; Copper ; Copper - chemistry ; Energy sources ; Enzymes ; Greenhouse gases ; Iron ; Methane ; Methanol ; Microbiology ; Mixed Function Oxygenases ; Oxidation ; Oxidation-Reduction ; Oxygenases - metabolism ; Quaternary
  • É parte de: Chemical reviews, 2024-02, Vol.124 (3), p.1288-1320
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Methane is a potent greenhouse gas that contributes significantly to climate change and is primarily regulated in Nature by methanotrophic bacteria, which consume methane gas as their source of energy and carbon, first by oxidizing it to methanol. The direct oxidation of methane to methanol is a chemically difficult transformation, accomplished in methanotrophs by complex methane monooxygenase (MMO) enzyme systems. These enzymes use iron or copper metallocofactors and have been the subject of detailed investigation. While the structure, function, and active site architecture of the copper-dependent particulate methane monooxygenase (pMMO) have been investigated extensively, its putative quaternary interactions, regulation, requisite cofactors, and mechanism remain enigmatic. The iron-dependent soluble methane monooxygenase (sMMO) has been characterized biochemically, structurally, spectroscopically, and, for the most part, mechanistically. Here, we review the history of MMO research, focusing on recent developments and providing an outlook for future directions of the field. Engineered biological catalysis systems and bioinspired synthetic catalysts may continue to emerge along with a deeper understanding of the molecular mechanisms of biological methane oxidation. Harnessing the power of these enzymes will necessitate combined efforts in biochemistry, structural biology, inorganic chemistry, microbiology, computational biology, and engineering.
  • Editor: United States: American Chemical Society
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.