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Genetically determined electrophoretic variants of the major urinary protein (Mup) complex in mouse urine

Groen, A ; Lagerwerf, A.J

Animal Blood Groups and Biochemical Genetics, 1979-01, Vol.10 (2), p.107-114 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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  • Título:
    Genetically determined electrophoretic variants of the major urinary protein (Mup) complex in mouse urine
  • Autor: Groen, A ; Lagerwerf, A.J
  • Assuntos: Alleles ; animal breeding ; animal science ; Animals ; cellogel electrophoresis ; Crosses, Genetic ; Electrophoresis, Cellulose Acetate ; Electrophoresis, Starch Gel ; Female ; Gene Frequency ; Genetic Variation ; livestock ; major urinary protein complex ; Male ; Mice ; Mice, Inbred Strains - genetics ; mouse ; Phenotype ; Proteinuria - genetics ; Sex Factors ; starch gel electrophoresis
  • É parte de: Animal Blood Groups and Biochemical Genetics, 1979-01, Vol.10 (2), p.107-114
  • Notas: ark:/67375/WNG-VQPM32ML-9
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    content type line 23
  • Descrição: Summary The major urinary protein (Mup‐complex) excreted in mouse urine, has been studied electrophoretically both on starch gel and on cellogel. On stargel six anodally migrating protein bands were observed. These bands are designated component 3, 2′, 2, 1, and 4 (i.e. two bands) in the order of decreasing mobility toward the anode. The slower protein band of component 4 on starch gel was not observed on cellogel. By testing mouse inbred strains, we were able to dinstinguish five male and four female Mup phenotypes. Test crosses suggested a four‐allelic (a, b, c, d,) variation with regard to components 2′, 2 and 1: ‘group A’ strains showed component 1, ‘group B’ strains components 1 and 2, ‘group C’ and ‘group F strains none, and ‘group D’ strains showed components 1 and 2’. Component 3 may be encoded by another Mup locus, although no crossing‐over has been observed: presence (A, B, D, and F strains), absence (C strains). Insufficiently reproducible demonstration of the variation with regard to component 4, forced us to exclude this component for strain distinction. The Mup phenotypes described, can be useful for the detection of certain strain contaminations, especially if F1 hybrid Mup phenotypes are distinguishable
  • Editor: Oxford, UK: Blackwell Publishing Ltd
  • Idioma: Inglês
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