Idioma:

Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions

Cassells, Irwin ; Stringer, Tameryn ; Hutton, Alan T. ; Prince, Sharon ; Smith, Gregory S.

Journal of biological inorganic chemistry, 2018-07, Vol.23 (5), p.763-774 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

Texto completo disponível

Citações Citado por

Enviar para

Título:
Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions
Autor: Cassells, Irwin ; Stringer, Tameryn ; Hutton, Alan T. ; Prince, Sharon ; Smith, Gregory S.
Assuntos: Biochemistry ; Biomedical and Life Sciences ; Breast cancer ; Cisplatin ; Crystallography, X-Ray ; Cytotoxicity ; Deoxyribonucleic acid ; Diffraction ; DNA ; DNA - chemistry ; Humans ; Iridium - chemistry ; Life Sciences ; Lipophilic ; Mass spectroscopy ; MCF-7 Cells ; Microbiology ; NMR ; Nuclear magnetic resonance ; Organometallic Compounds - chemistry ; Original Paper ; p-Cymene ; Platinum ; Rhodium ; Rhodium - chemistry ; Ruthenium - chemistry ; Spectrum Analysis - methods ; X-ray diffraction
É parte de: Journal of biological inorganic chemistry, 2018-07, Vol.23 (5), p.763-774
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A series of bidentate salicylaldimine ligands was prepared and reacted with either [RuCl(µ-Cl)( p -cymene)] 2 , [RhCl(µ-Cl)(Cp*)] 2 or [IrCl(µ-Cl)(Cp*)] 2 . All of the compounds were characterised using an array of spectroscopic and analytical techniques, namely, nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy and mass spectrometry. Single crystal X-ray diffraction (XRD) was used to confirm the bidentate coordination mode of the salicylaldimine ligand to the metal centre. The platinum group metal (PGM) complexes were screened against the MCF7 breast cancer cell line. The ruthenium and iridium salicylaldimine complexes showed comparable or greater cytotoxicity than cisplatin against the MCF7 cancer cells, as well as greater cytotoxicity than their rhodium counterparts. Three of the salicylaldimine complexes showed potent activity in the range 18–21 µM. Two of these complexes had a greater affinity for cancerous cells than for CHO non-cancerous cells (SI > 4). Preliminary mechanistic studies suggest that the ruthenium complexes undergo solvation prior to 5′-GMP binding, whereas the iridium complexes were inert to the solvation process. Graphical abstract
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions

Cassells, Irwin ; Stringer, Tameryn ; Hutton, Alan T. ; Prince, Sharon ; Smith, Gregory S.

Berlin/Heidelberg: Springer Berlin Heidelberg

Buscando em bases de dados remotas. Favor aguardar.