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Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality

Unger, Allison L ; Eckstrom, Korin ; Jetton, Thomas L ; Kraft, Jana Loor, Juan J

PloS one, 2019-12, Vol.14 (12), p.e0226635-e0226635 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality
Autor: Unger, Allison L ; Eckstrom, Korin ; Jetton, Thomas L ; Kraft, Jana
Loor, Juan J
Assuntos: Abundance ; Age ; Age Factors ; Aging ; Animals ; Bacteria ; Bacteroides - drug effects ; Bacteroides - growth & development ; Bacteroidetes ; Biodiversity ; Biology and Life Sciences ; Colon - microbiology ; Composition ; Diabetes ; Diet ; Dietary fat ; Dietary Fats - pharmacology ; Dietary supplements ; Disease control ; Disease prevention ; Echium oil ; Ecology and Environmental Sciences ; Efficiency ; Endocrinology ; Fatty acid composition ; Fatty acids ; Feeds ; Female ; Females ; Fish oils ; Fish Oils - pharmacology ; Gastrointestinal Microbiome - drug effects ; Gender aspects ; Inflammation ; Intestinal microflora ; Male ; Males ; Medicine and Health Sciences ; Metabolism ; Mice ; Microbiota ; Microbiota (Symbiotic organisms) ; Oils & fats ; Plant Oils - pharmacology ; Population ; Population genetics ; Population studies ; Relative abundance ; Sex ; Sex differences ; Sex Factors ; Sexes
É parte de: PloS one, 2019-12, Vol.14 (12), p.e0226635-e0226635
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Evidence suggests that sex influences the effect of diet on the gut bacterial composition, yet, no studies have been performed assessing dietary fatty acid composition (i.e., fat quality) in this context. This study examined the effect of dietary fat quality on colonic bacterial composition in an aged, genetically-diverse mouse population. CD-1 mice were fed isoenergetic diets consisting of (1) control fat (CO; "Western-style" fat blend), (2) CO supplemented with 30% fish oil, (3) CO supplemented with 30% dairy fat, or (4) CO supplemented with 30% echium oil. Fecal samples were collected at mid-life and aged (reproductively senescent) time points. Overall, the abundance of Bacteroidetes was greater in mice fed echium oil compared to mice fed the control fat. Examination of colonic bacterial relative abundance also revealed sex differences, with 73 bacterial taxa being differentially expressed in males and females. Notably, results showed a strong interactive effect among the diet, sex, and age of mice which influenced colonic bacterial relative abundance and alpha diversity. In males, supplementation of the diet with dairy fat or echium oil caused the abundance of Bacteroidetes and Bacteroides to change with age. Additionally, supplementation of the diet with fish oil induced sex-dependent changes in the alpha diversity of aged mice compared to mid-life. This work supports that sex is a critical factor in colonic bacterial composition of an aged, genetically-heterogenous population. Moreover, this study establishes that the effectiveness of dietary interventions for health maintenance and disease prevention via direct or indirect manipulation of the gut microbiota is likely dependent on an individual's sex, age, and genetic background.
Editor: United States: Public Library of Science
Idioma: Inglês

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Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality

Unger, Allison L ; Eckstrom, Korin ; Jetton, Thomas L ; Kraft, Jana Loor, Juan J

United States: Public Library of Science

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