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Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release?

Bijlsma, Elisabeth Y. ; Chan, Johnny S.W. ; Olivier, Berend ; Veening, Jan G. ; Millan, Mark J. ; Waldinger, Marcel D. ; Oosting, Ronald S.

Pharmacology, biochemistry and behavior, 2014-06, Vol.121, p.88-101 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release?
Autor: Bijlsma, Elisabeth Y. ; Chan, Johnny S.W. ; Olivier, Berend ; Veening, Jan G. ; Millan, Mark J. ; Waldinger, Marcel D. ; Oosting, Ronald S.
Assuntos: Animal model ; Animals ; Antidepressants ; Antidepressive Agents - adverse effects ; Aza Compounds - adverse effects ; Brain - drug effects ; Brain - physiopathology ; Bridged Bicyclo Compounds, Heterocyclic - adverse effects ; Bupropion - adverse effects ; Buspirone - adverse effects ; Cyclohexanols - adverse effects ; Disease Models, Animal ; Dopamine - physiology ; Drug-induced ; Ejaculation ; Female ; Humans ; Indoles - adverse effects ; Male ; Norepinephrine - physiology ; Paroxetine - adverse effects ; Pyridines - adverse effects ; Rats ; Rats, Wistar ; Serotonin - physiology ; Serotonin Uptake Inhibitors - adverse effects ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Sexual Behavior, Animal - physiology ; Sexual dysfunction ; Sexual Dysfunction, Physiological - chemically induced ; Sexual Dysfunction, Physiological - physiopathology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Venlafaxine Hydrochloride
É parte de: Pharmacology, biochemistry and behavior, 2014-06, Vol.121, p.88-101
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Antidepressant-induced sexual dysfunction adversely affects the quality of life of antidepressant users and reduces compliance with treatment. Animal models provide an instructive approach for examining potential sexual side effects of novel drugs. This review discusses the stability and reproducibility of our standardized test procedure that assesses the acute, subchronic and chronic effects of psychoactive compounds in a 30minute mating test. In addition, we present an overview of the effects of several different (putative) antidepressants on male rat sexual behavior, as tested in our standardized test procedure. By comparing the effects of these mechanistically distinct antidepressants (paroxetine, venlafaxine, bupropion, buspirone, DOV 216,303 and S32006), this review discusses the putative mechanism underlying sexual side effects of antidepressants and their normalization. This review shows that sexual behavior is mainly inhibited by antidepressants that increase serotonin neurotransmission via blockade of serotonin transporters, while those that mainly increase the levels of dopamine and noradrenaline are devoid of sexual side effects. Those sexual disturbances cannot be normalized by simultaneously increasing noradrenaline neurotransmission, but are normalized by increasing both noradrenaline and dopamine neurotransmission. Therefore, it is hypothesized that the sexual side effects of selective serotonin reuptake inhibitors may be mediated by their inhibitory effects on dopamine signaling in sex brain circuits. Clinical development of novel antidepressants should therefore focus on compounds that simultaneously increase both serotonin and dopamine signaling. •Antidepressants (AD) that block SERT inhibit sexual behavior.•AD that increase dopamine and noradrenaline do not inhibit sexual behavior.•SERT-mediated inhibition is counteracted by increasing dopamine and noradrenaline.•SSRI-induced sexual side effects may be due to inhibition of dopamine signaling.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release?

Bijlsma, Elisabeth Y. ; Chan, Johnny S.W. ; Olivier, Berend ; Veening, Jan G. ; Millan, Mark J. ; Waldinger, Marcel D. ; Oosting, Ronald S.

United States: Elsevier Inc

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