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Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

Perlow, Mark J. ; Freed, William J. ; Hoffer, Barry J. ; Seiger, Ake ; Olson, Lars ; Wyatt, Richard Jed

Science (American Association for the Advancement of Science), 1979-05, Vol.204 (4393), p.643-647 [Revista revisada por pares]

United States: American Association for the Advancement of Science

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Título:
Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System
Autor: Perlow, Mark J. ; Freed, William J. ; Hoffer, Barry J. ; Seiger, Ake ; Olson, Lars ; Wyatt, Richard Jed
Materias: Animals ; Brain ; Brain research ; Case studies ; Catecholamines ; Caudate nucleus ; Corpus Striatum - physiology ; Disease Models, Animal ; Dopamine ; Graft Survival ; Humans ; Hydroxydopamines - toxicity ; Lateral ventricles ; Lesions ; Male ; Movement Disorders - physiopathology ; Nerve tissue ; Neurons ; Organ transplantation ; Parkinson Disease - therapy ; Parkinsonism ; Rats ; Rotation ; Sciatic nerve ; Stereotyped Behavior - physiology ; Substantia Nigra - embryology ; Substantia Nigra - physiology ; Substantia Nigra - transplantation ; Tissue grafting ; Tissue transplantation ; Transplantation ; Transplantation of organs, tissues, etc ; Transplantation, Homologous
Es parte de: Science (American Association for the Advancement of Science), 1979-05, Vol.204 (4393), p.643-647
Descripción: In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglés

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Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

Perlow, Mark J. ; Freed, William J. ; Hoffer, Barry J. ; Seiger, Ake ; Olson, Lars ; Wyatt, Richard Jed

United States: American Association for the Advancement of Science

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