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A simple genetic architecture underlies morphological variation in dogs

Boyko, Adam R ; Quignon, Pascale ; Li, Lin ; Schoenebeck, Jeffrey J ; Degenhardt, Jeremiah D ; Lohmueller, Kirk E ; Zhao, Keyan ; Brisbin, Abra ; Parker, Heidi G ; vonHoldt, Bridgett M ; Cargill, Michele ; Auton, Adam ; Reynolds, Andy ; Elkahloun, Abdel G ; Castelhano, Marta ; Mosher, Dana S ; Sutter, Nathan B ; Johnson, Gary S ; Novembre, John ; Hubisz, Melissa J ; Siepel, Adam ; Wayne, Robert K ; Bustamante, Carlos D ; Ostrander, Elaine A Hoekstra, Hopi E.

PLoS Biology, 2010-08, Vol.8 (8), p.e1000451-e1000451 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
A simple genetic architecture underlies morphological variation in dogs
Autor: Boyko, Adam R ; Quignon, Pascale ; Li, Lin ; Schoenebeck, Jeffrey J ; Degenhardt, Jeremiah D ; Lohmueller, Kirk E ; Zhao, Keyan ; Brisbin, Abra ; Parker, Heidi G ; vonHoldt, Bridgett M ; Cargill, Michele ; Auton, Adam ; Reynolds, Andy ; Elkahloun, Abdel G ; Castelhano, Marta ; Mosher, Dana S ; Sutter, Nathan B ; Johnson, Gary S ; Novembre, John ; Hubisz, Melissa J ; Siepel, Adam ; Wayne, Robert K ; Bustamante, Carlos D ; Ostrander, Elaine A
Hoekstra, Hopi E.
Assuntos: Animals ; Animals, Domestic - anatomy & histology ; Animals, Domestic - genetics ; Body Size ; Dogs ; Dogs - anatomy & histology ; Evolutionary Biology/Animal Genetics ; Evolutionary Biology/Genomics ; Genetic aspects ; Genetic Variation ; Genetics ; Genetics and Genomics/Animal Genetics ; Genetics and Genomics/Complex Traits ; Genetics and Genomics/Genomics ; Genetics and Genomics/Population Genetics ; Genome ; Genome-Wide Association Study ; Genomics ; Genotype & phenotype ; Life Sciences ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Single nucleotide polymorphisms
É parte de: PLoS Biology, 2010-08, Vol.8 (8), p.e1000451-e1000451
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ARB PQ LL KEL AB RKW CDB EAO. Performed the experiments: ARB PQ LL JJS JDD KEL AB HGP BMv AA AR AGE JN. Analyzed the data: ARB PQ LL JDD KEL KZ AB HGP BMv AA AR JN CDB. Contributed reagents/materials/analysis tools: ARB PQ LL KEL KZ BMv MC AA AGE MC DSM NBS GJ MJH AS RKW CDB EAO. Wrote the paper: ARB PQ LL JDD KEL RKW CDB.
These authors co-directed the work.
Descrição: Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (< or = 3) explain the majority of phenotypic variation for most of the traits we studied. In addition, many genomic regions show signatures of recent selection, with most of the highly differentiated regions being associated with breed-defining traits such as body size, coat characteristics, and ear floppiness. Our results demonstrate the efficacy of mapping multiple traits in the domestic dog using a database of genotyped individuals and highlight the important role human-directed selection has played in altering the genetic architecture of key traits in this important species.
Editor: United States: Public Library of Science
Idioma: Inglês

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A simple genetic architecture underlies morphological variation in dogs

United States: Public Library of Science

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