Idioma:

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, Roland R. ; Johnson, Matthew W. ; Richards, William A. ; Richards, Brian D. ; McCann, Una ; Jesse, Robert

Psychopharmacologia, 2011-12, Vol.218 (4), p.649-665 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

Texto completo disponível

Citações Citado por

Enviar para

Título:
Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
Autor: Griffiths, Roland R. ; Johnson, Matthew W. ; Richards, William A. ; Richards, Brian D. ; McCann, Una ; Jesse, Robert
Assuntos: Adult ; Affect - drug effects ; Anxiety ; Attitude ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug therapy ; Fear ; Female ; Follow-Up Studies ; Hallucinogenic drugs ; Hallucinogens - administration & dosage ; Hallucinogens - pharmacology ; Humans ; Inventories ; Male ; Medical sciences ; Middle Aged ; Mood ; Neuropharmacology ; Neurosciences ; Original Investigation ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Psilocybin - administration & dosage ; Psilocybin - pharmacology ; Psilocybine ; Psychiatry ; Psychodysleptics: hallucinogen ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Spirituality ; Surveys and Questionnaires ; Time Factors
É parte de: Psychopharmacologia, 2011-12, Vol.218 (4), p.649-665
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Rationale This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. Objectives This double-blind study evaluated psilocybin (0, 5, 10, 20, 30 mg/70 kg, p.o.) administered under supportive conditions. Methods Participants were 18 adults (17 hallucinogen-naïve). Five 8-h sessions were conducted individually for each participant at 1-month intervals. Participants were randomized to receive the four active doses in either ascending or descending order (nine participants each). Placebo was scheduled quasi-randomly. During sessions, volunteers used eyeshades and were instructed to direct their attention inward. Volunteers completed questionnaires assessing effects immediately after and 1 month after each session, and at 14 months follow-up. Results Psilocybin produced acute perceptual and subjective effects including, at 20 and/or 30 mg/70 kg, extreme anxiety/fear (39% of volunteers) and/or mystical-type experience (72% of volunteers). One month after sessions at the two highest doses, volunteers rated the psilocybin experience as having substantial personal and spiritual significance, and attributed to the experience sustained positive changes in attitudes, mood, and behavior, with the ascending dose sequence showing greater positive effects. At 14 months, ratings were undiminished and were consistent with changes rated by community observers. Both the acute and persisting effects of psilocybin were generally a monotonically increasing function of dose, with the lowest dose showing significant effects. Conclusions Under supportive conditions, 20 and 30 mg/70 kg psilocybin occasioned mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. Implications for therapeutic trials are discussed.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, Roland R. ; Johnson, Matthew W. ; Richards, William A. ; Richards, Brian D. ; McCann, Una ; Jesse, Robert

Berlin/Heidelberg: Springer-Verlag

Buscando em bases de dados remotas. Favor aguardar.