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Human-sized magnetic particle imaging for brain applications

Graeser, M ; Thieben, F ; Szwargulski, P ; Werner, F ; Gdaniec, N ; Boberg, M ; Griese, F ; Möddel, M ; Ludewig, P ; van de Ven, D ; Weber, O M ; Woywode, O ; Gleich, B ; Knopp, T

Nature communications, 2019-04, Vol.10 (1), p.1936-9, Article 1936 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Human-sized magnetic particle imaging for brain applications
Autor: Graeser, M ; Thieben, F ; Szwargulski, P ; Werner, F ; Gdaniec, N ; Boberg, M ; Griese, F ; Möddel, M ; Ludewig, P ; van de Ven, D ; Weber, O M ; Woywode, O ; Gleich, B ; Knopp, T
Assuntos: Brain ; Brain - diagnostic imaging ; Brain - pathology ; Cerebrovascular Disorders - diagnostic imaging ; Cerebrovascular Disorders - pathology ; Contrast Media - chemistry ; Contrast Media - metabolism ; Dextrans - chemistry ; Dextrans - metabolism ; Diagnosis ; Diagnostic systems ; Hemorrhage ; Hospitals ; Humans ; Intensive care ; Intensive Care Units ; Intracranial Hemorrhages - diagnostic imaging ; Intracranial Hemorrhages - pathology ; Iron ; Magnetics - instrumentation ; Magnetics - methods ; Magnetite Nanoparticles - chemistry ; Medical imaging ; Neuroimaging ; Neuroimaging - instrumentation ; Neuroimaging - methods ; Particle Size ; Perfusion ; Phantoms, Imaging ; Restenosis ; Stroke - diagnostic imaging ; Stroke - pathology ; Tomography - instrumentation ; Tomography - methods ; Vascular diseases
É parte de: Nature communications, 2019-04, Vol.10 (1), p.1936-9, Article 1936
Descrição: Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmol ml , which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Human-sized magnetic particle imaging for brain applications

Graeser, M ; Thieben, F ; Szwargulski, P ; Werner, F ; Gdaniec, N ; Boberg, M ; Griese, F ; Möddel, M ; Ludewig, P ; van de Ven, D ; Weber, O M ; Woywode, O ; Gleich, B ; Knopp, T

England: Nature Publishing Group

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