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Synthetic biology strategies for microbial biosynthesis of plant natural products

Cravens, Aaron ; Payne, James ; Smolke, Christina D

Nature communications, 2019-05, Vol.10 (1), p.2142-2142, Article 2142 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Synthetic biology strategies for microbial biosynthesis of plant natural products
Autor: Cravens, Aaron ; Payne, James ; Smolke, Christina D
Assuntos: Biological Products - metabolism ; Biosynthesis ; Biosynthetic Pathways - genetics ; Enzymes - genetics ; Enzymes - metabolism ; Escherichia coli - genetics ; Escherichia coli - metabolism ; Escherichia coli Proteins - genetics ; Escherichia coli Proteins - metabolism ; Fragrances ; Historical account ; Manufacturing industry ; Medicinal plants ; Medicine ; Metabolic engineering ; Metabolic Engineering - methods ; Metabolic Engineering - trends ; Metabolism ; Microorganisms ; Microorganisms, Genetically-Modified - genetics ; Microorganisms, Genetically-Modified - metabolism ; Natural products ; Organic chemistry ; Plants - metabolism ; Review ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Synthetic Biology - methods ; Synthetic Biology - trends
É parte de: Nature communications, 2019-05, Vol.10 (1), p.2142-2142, Article 2142
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Synthetic biology strategies for microbial biosynthesis of plant natural products

Cravens, Aaron ; Payne, James ; Smolke, Christina D

England: Nature Publishing Group

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