Idioma:

The Impact of Tumor Multifocality on Outcomes in Patients Treated With Radical Nephroureterectomy

Chromecki, Thomas F ; Cha, Eugene K ; Fajkovic, Harun ; Margulis, Vitaly ; Novara, Giacomo ; Scherr, Douglas S ; Lotan, Yair ; Raman, Jay D ; Kassouf, Wassim ; Bensalah, Karim ; Weizer, Alon ; Kikuchi, Eiji ; Roscigno, Marco ; Remzi, Mesut ; Matsumoto, Kazumasa ; Walton, Thomas J ; Pycha, Armin ; Ficarra, Vincenzo ; Karakiewicz, Pierre I ; Zigeuner, Richard ; Pummer, Karl ; Shariat, Shahrokh F

European urology, 2012-02, Vol.61 (2), p.245-253 [Periódico revisado por pares]

Kidlington: Elsevier B.V

Texto completo disponível

Citações Citado por

Enviar para

Título:
The Impact of Tumor Multifocality on Outcomes in Patients Treated With Radical Nephroureterectomy
Autor: Chromecki, Thomas F ; Cha, Eugene K ; Fajkovic, Harun ; Margulis, Vitaly ; Novara, Giacomo ; Scherr, Douglas S ; Lotan, Yair ; Raman, Jay D ; Kassouf, Wassim ; Bensalah, Karim ; Weizer, Alon ; Kikuchi, Eiji ; Roscigno, Marco ; Remzi, Mesut ; Matsumoto, Kazumasa ; Walton, Thomas J ; Pycha, Armin ; Ficarra, Vincenzo ; Karakiewicz, Pierre I ; Zigeuner, Richard ; Pummer, Karl ; Shariat, Shahrokh F
Assuntos: Aged ; Aged, 80 and over ; Bioengineering ; Biological and medical sciences ; Cancer-specific survival ; Carcinoma ; Carcinoma - mortality ; Carcinoma - surgery ; Disease Progression ; Female ; Human health and pathology ; Humans ; Kidney Neoplasms ; Kidney Neoplasms - mortality ; Kidney Neoplasms - surgery ; Life Sciences ; Male ; Medical sciences ; Middle Aged ; Multifocal ; Neoplasm Recurrence, Local ; Neoplasm Recurrence, Local - surgery ; Nephrectomy ; Nephrectomy - methods ; Nephrology. Urinary tract diseases ; Prognosis ; Radical nephroureterectomy ; Retrospective Studies ; Survival ; Survival Rate ; Treatment Outcome ; Ureter ; Ureter - surgery ; Ureteral Neoplasms ; Ureteral Neoplasms - mortality ; Ureteral Neoplasms - surgery ; Urinary tract cancer ; Urology ; Urology and Nephrology ; Urothelial carcinoma
É parte de: European urology, 2012-02, Vol.61 (2), p.245-253
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Background The prognostic impact of multifocal upper-tract urothelial carcinoma (UTUC) is poorly understood. Objective To investigate the association between tumor multifocality and clinicopathologic features and outcomes of UTUC in patients managed by radical nephroureterectomy (RNU). Design, setting, and participants The study included 2492 patients treated with either open or laparoscopic RNU. Tumor and patient characteristics included tumor stage, tumor grade, lymph node status, lymphovascular invasion (LVI), tumor architecture, tumor location, unifocal or multifocal disease, gender, age, history of bladder cancer (BCa), Eastern Cooperative Oncology Group (ECOG) performance status (PS), and adjuvant chemotherapy. tumor multifocality of UTUC was defined as the synchronous presence of multiple tumors in the renal pelvis or ureter. Intervention All patients were treated with either open or laparoscopic RNU. Measurements Univariable and multivariable models tested the effect of tumor multifocality on disease progression and cancer-specific mortality. Results and limitations Five hundred ninety patients (23.7%) had tumor multifocality at the time of RNU. The median follow-up was 45 mo (interquartile range [IQR]: 0–101). Tumor multifocality was significantly associated with a history of previous BCa ( p = 0.032), lymph node involvement ( p = 0.036), tumor location in the ureter ( p = 0.003), higher tumor stage ( p < 0.001), higher tumor grade ( p < 0.001), sessile tumor architecture ( p = 0.003), and LVI ( p = 0.001). In organ-confined patients, tumor multifocality was an independent predictor of both disease progression (hazard ratio [HR]: 1.43; p = 0.019) and cancer-specific mortality (HR: 1.46; p = 0.027). When assessed in all patients, tumor multifocality was associated with both disease progression and cancer-specific mortality in univariable ( p = 0.005 and p = 0.006, respectively) but not in multivariable analyses ( p = 0.468 and p = 0.798, respectively). The main limitation is the retrospective design of the study. Conclusions Tumor multifocality is an independent prognosticator of disease progression and cancer-specific mortality in patients with organ-confined UTUC treated with RNU. Multifocal organ-confined patients with UTUC may need closer follow-up. Integration of tumor multifocality with other factors may help identify those patients who would benefit from multimodal therapy.
Editor: Kidlington: Elsevier B.V
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

The Impact of Tumor Multifocality on Outcomes in Patients Treated With Radical Nephroureterectomy

Kidlington: Elsevier B.V

Buscando em bases de dados remotas. Favor aguardar.