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Molecular mobility and fragility in indomethacin: A thermally stimulated depolarization current study

CORREIA, Natalia T ; MOURA RAMOS, Joaquim J ; DESCAMPS, Marc ; COLLINS, George

Pharmaceutical research, 2001-12, Vol.18 (12), p.1767-1774 [Periódico revisado por pares]

New York, NY: Springer

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  • Título:
    Molecular mobility and fragility in indomethacin: A thermally stimulated depolarization current study
  • Autor: CORREIA, Natalia T ; MOURA RAMOS, Joaquim J ; DESCAMPS, Marc ; COLLINS, George
  • Assuntos: Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Calorimetry ; Chemical Phenomena ; Chemistry, Physical ; Electric fields ; Experiments ; Indomethacin - chemistry ; Medical sciences ; Models, Chemical ; Molecular Structure ; Pharmaceuticals ; Pharmacology. Drug treatments ; Temperature
  • É parte de: Pharmaceutical research, 2001-12, Vol.18 (12), p.1767-1774
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: To show that thermally stimulated depolarization currents (TSDC), which is a dielectric experimental technique relatively unknown in the pharmaceutical scientists community, is a powerful technique to study molecular mobility in pharmaceutical solids, below their glass transition temperature (Tg). Indomethacin (Tg = 42 degrees C) is used as a model compound. TSDC is used to isolate the individual modes of motion present in indomethacin, in the temperature range between -165 degrees C and +60 degrees C. From the experimental output of the TSDC experiments, the kinetic parameters associated with the different relaxational modes of motion were obtained, which allowed a detailed characterization of the distribution of relaxation times of the complex relaxations observed in indomethacin. Two different relaxational processes were detected and characterized: the glass transition relaxation, or alpha-process, and a sub-Tg relaxation, or secondary process. The lower temperature secondary process presents a very low intensity, a very low activation energy, and a very low degree of cooperativity. The fragility index (Angell's scale) of indomethacin obtained from TSDC data is m = 64, which can be compared with other values reported in the literature and obtained from other experimental techniques. TSDC data indicate that indomethacin is a relatively strong glass former (fragility similar to glycerol but lower than sorbitol, trehalose, and sucrose). The high-resolution power of the TSDC technique is illustrated by the fact that it detected and characterized the secondary relaxation in indomethacin, which was not possible by other techniques.
  • Editor: New York, NY: Springer
  • Idioma: Inglês
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