Idioma:

Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD

Hersh, Craig P ; Washko, George R ; Estépar, Raúl San José ; Lutz, Sharon ; Friedman, Paul J ; Han, MeiLan K ; Hokanson, John E ; Judy, Philip F ; Lynch, David A ; Make, Barry J ; Marchetti, Nathaniel ; Newell, Jr, John D ; Sciurba, Frank C ; Crapo, James D ; Silverman, Edwin K

Respiratory research, 2013-04, Vol.14 (1), p.42-42, Article 42 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
Autor: Hersh, Craig P ; Washko, George R ; Estépar, Raúl San José ; Lutz, Sharon ; Friedman, Paul J ; Han, MeiLan K ; Hokanson, John E ; Judy, Philip F ; Lynch, David A ; Make, Barry J ; Marchetti, Nathaniel ; Newell, Jr, John D ; Sciurba, Frank C ; Crapo, James D ; Silverman, Edwin K
Assuntos: Analysis ; Chronic obstructive pulmonary disease ; Colleges & universities ; Comorbidity ; CT imaging ; Development and progression ; Diagnosis ; Disease ; Drug dosages ; Epidemiology ; Family medical history ; Female ; Humans ; Lung diseases, Obstructive ; Lungs ; Male ; Medicine ; Middle Aged ; Pharmaceutical industry ; Prevalence ; Pulmonary Alveoli - diagnostic imaging ; Pulmonary Alveoli - physiopathology ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Emphysema - diagnostic imaging ; Pulmonary Emphysema - epidemiology ; Pulmonary Emphysema - physiopathology ; Pulmonary function tests ; Radiographic Image Enhancement - methods ; Radiography, Thoracic ; Reproducibility of Results ; Respiratory Mechanics ; Respiratory physiology ; Sensitivity and Specificity ; Smoking - epidemiology ; Tomography, X-Ray Computed - methods ; Tomography, X-Ray Computed - statistics & numerical data ; United States - epidemiology ; Womens health
É parte de: Respiratory research, 2013-04, Vol.14 (1), p.42-42, Article 42
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Gas trapping quantified on chest CT scans has been proposed as a surrogate for small airway disease in COPD. We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease. Smokers with and without COPD from the COPDGene Study underwent inspiratory and expiratory chest CT scans. Emphysema was quantified by the percent of lung with attenuation < -950HU on inspiratory CT. Four gas trapping measures were defined: (1) Exp(-856), the percent of lung < -856HU on expiratory imaging; (2) E/I MLA, the ratio of expiratory to inspiratory mean lung attenuation; (3) RVC(856-950), the difference between expiratory and inspiratory lung volumes with attenuation between -856 and -950 HU; and (4) Residuals from the regression of Exp(-856) on percent emphysema. In 8517 subjects with complete data, Exp(-856) was highly correlated with emphysema. The measures based on paired inspiratory and expiratory CT scans were less strongly correlated with emphysema. Exp(-856), E/I MLA and RVC(856-950) were predictive of spirometry, exercise capacity and quality of life in all subjects and in subjects without emphysema. In subjects with severe emphysema, E/I MLA and RVC(856-950) showed the highest correlations with clinical variables. Quantitative measures based on paired inspiratory and expiratory chest CT scans can be used as markers of small airway disease in smokers with and without COPD, but this will require that future studies acquire both inspiratory and expiratory CT scans.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 2 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD

Hersh, Craig P ; Washko, George R ; Estépar, Raúl San José ; Lutz, Sharon ; Friedman, Paul J ; Han, MeiLan K ; Hokanson, John E ; Judy, Philip F ; Lynch, David A ; Make, Barry J ; Marchetti, Nathaniel ; Newell, Jr, John D ; Sciurba, Frank C ; Crapo, James D ; Silverman, Edwin K

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.