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Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers

Curran, H.Valerie ; Gorenstein, Clarice ; Lader, Malcolm

Journal of psychopharmacology (Oxford), 1993-01, Vol.7 (3), p.249-256 [Periódico revisado por pares]

Thousand Oaks, CA: Sage Publications

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Título:
Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers
Autor: Curran, H.Valerie ; Gorenstein, Clarice ; Lader, Malcolm
Assuntos: Amnesia ; Benzodiazepines ; Between-subjects design ; Biological and medical sciences ; Blindness ; Drug toxicity and drugs side effects treatment ; Lorazepam ; Medical sciences ; Mental task performance ; Mood ; Pharmacology. Drug treatments ; Toxicity: nervous system and muscle
É parte de: Journal of psychopharmacology (Oxford), 1993-01, Vol.7 (3), p.249-256
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Oxazepam and its chlorinated derivative, lorazepam, have similar half-lives but differing potencies. This study compared the effects of these two benzodiazepines with a placebo on memory, mood and psychomotor function. Thirty six volunteers took part in a double-blind, independent groups design. Subjects completed a battery of tests before and 2.5 h after drug administration. Lorazepam 2 mg produced more profound subjective and motor sedation than oxazepam 30 mg, and this in turn produced a similar, global pattern of impairments across a wide range of tasks. However, lorazepam produced greater decrements than oxazepam on a task involving episodic memory even when sedative effects were partialled out. We suggest that this finding may reflect either differential task sensitivities or a contribution of priming to performance on the explicit memory task.
Editor: Thousand Oaks, CA: Sage Publications
Idioma: Inglês

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Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers

Curran, H.Valerie ; Gorenstein, Clarice ; Lader, Malcolm

Thousand Oaks, CA: Sage Publications

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