Idioma:

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis

Ahn, Jeonghyun ; Son, Sehee ; Oliveira, Sergio C. ; Barber, Glen N.

Cell reports (Cambridge), 2017-12, Vol.21 (13), p.3873-3884 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis
Autor: Ahn, Jeonghyun ; Son, Sehee ; Oliveira, Sergio C. ; Barber, Glen N.
Assuntos: Animals ; CAC ; Cell Lineage ; Colitis - metabolism ; Colitis - pathology ; colitis-associated cancer ; Colonic Polyps - metabolism ; Colonic Polyps - pathology ; Host-Pathogen Interactions ; IBD ; IL-10 ; Inflammation - metabolism ; Inflammation - pathology ; inflammatory bowel disease ; Interleukin-10 - metabolism ; Membrane Proteins - deficiency ; Membrane Proteins - metabolism ; Mice, Knockout ; Models, Biological ; Monocytes - metabolism ; Myeloid Differentiation Factor 88 - metabolism ; Signal Transduction ; STING
É parte de: Cell reports (Cambridge), 2017-12, Vol.21 (13), p.3873-3884
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Intestinal immune homeostasis is preserved by commensal bacteria interacting with the host to generate a balanced array of cytokines that are essential for wound repair and for combatting infection. Inflammatory bowel disease (IBD), which can lead to colitis-associated cancer (CAC), is thought to involve chronic microbial irritation following a breach of the mucosal intestinal epithelium. However, the innate immune pathways responsible for regulating these inflammatory processes remain to be fully clarified. Here, we show that commensal bacteria influence STING signaling predominantly in mononuclear phagocytes to produce both pro-inflammatory cytokines as well as anti-inflammatory IL-10. Enterocolitis, manifested through loss of IL-10, was completely abrogated in the absence of STING. Intestinal inflammation was less severe in the absence of cGAS, possibly suggesting a role for cyclic dinucleotides (CDNs) indirectly regulating STING signaling. Our data shed insight into the causes of inflammation and provide a potential therapeutic target for prevention of IBD. [Display omitted] •Commensal bacteria stimulate STING signaling to control gut homeostasis•Both pro- and anti-inflammatory (IL-10) cytokines expression is stimulated by STING•STING-dependent pro-inflammatory cytokine activity is balanced by IL-10 production•Monocyte lineages are primarily accountable for STING-mediated cytokine expression Ahn et al. find a key role for STING signaling in controlling gut homeostasis. Loss of STING reverses colitis observed in the absence of the anti-inflammatory cytokine IL-10 in mice. The interface of commensal bacteria with mononuclear phagocytes (MNPs) containing STING is responsible for stimulating pro- as well as anti-inflammatory cytokine expression.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis

Ahn, Jeonghyun ; Son, Sehee ; Oliveira, Sergio C. ; Barber, Glen N.

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.