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Flux-based analysis of sulfur metabolism in desulfurizing strains of Rhodococcus erythropolis

Aggarwal, Shilpi ; Karimi, Iftekhar A ; Lee, Dong Yup

FEMS microbiology letters, 2011-02, Vol.315 (2), p.115-121 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Flux-based analysis of sulfur metabolism in desulfurizing strains of Rhodococcus erythropolis
Autor: Aggarwal, Shilpi ; Karimi, Iftekhar A ; Lee, Dong Yup
Assuntos: Bacteriology ; biodesulfurization ; Biological and medical sciences ; Biomass ; Carbohydrate Metabolism ; Carbon sources ; Catalysis ; Cell growth ; Citric acid ; DBT ; Desulfurization ; Desulfurizing ; Dibenzothiophene ; Ethanol ; Fructose ; Fundamental and applied biological sciences. Psychology ; Genetic engineering ; Glycerol ; Growth rate ; Lactic acid ; Metabolism ; Microbiology ; Miscellaneous ; Models, Biological ; Models, Statistical ; Rhodococcus ; Rhodococcus - growth & development ; Rhodococcus - metabolism ; Rhodococcus erythropolis ; stoichiometric model ; Sulfates ; Sulfur ; Sulfur - metabolism ; Thiophenes - metabolism
É parte de: FEMS microbiology letters, 2011-02, Vol.315 (2), p.115-121
Notas: http://dx.doi.org/10.1111/j.1574-6968.2010.02179.x
Editor: Christiane Dahl
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Descrição: Rhodococcus erythropolis has been studied widely for potential applications in biodesulfurization. Previous works have been largely experimental with an emphasis on the characterization and genetic engineering of desulfurizing strains for improved biocatalysis. A systems modeling approach that can complement these experimental efforts by providing useful insights into the complex interactions of desulfurization reactions with various other metabolic activities is absent in the literature. In this work, we report the first attempt at reconstructing a flux-based model to analyze sulfur utilization by R. erythropolis. The model includes the 4S pathway for dibenzothiophene (DBT) desulfurization. It predicts closely the growth rates reported by two independent experimental studies, and gives a clear and comprehensive picture of the pathways that assimilate the sulfur from DBT into biomass. In addition, it successfully elucidates that sulfate promotes higher cell growth than DBT and its presence in the medium reduces DBT desulfurization rates. A study using eight carbon sources suggests that ethanol and lactate yield higher cell growth and desulfurization rates than citrate, fructose, glucose, gluconate, glutamate, and glycerol.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Flux-based analysis of sulfur metabolism in desulfurizing strains of Rhodococcus erythropolis

Aggarwal, Shilpi ; Karimi, Iftekhar A ; Lee, Dong Yup

Oxford, UK: Blackwell Publishing Ltd

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