Idioma:

Evaluation of a multi‐agent chemotherapy protocol combining dexamethasone, melphalan, actinomycin D, and cytarabine for the treatment of resistant canine non‐Hodgkin high‐grade lymphomas: a single centre's experience

Smallwood, Katherine ; Tanis, Jean‐Benoit ; Grant, Iain A. ; Blackwood, Laura ; Killick, David R. ; Amores‐Fuster, Isabel ; Elliott, James ; Mas, Aran ; Harper, Aaron ; Marrington, Mary ; Finotello, Riccardo

Veterinary & comparative oncology, 2019-06, Vol.17 (2), p.165-173 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Evaluation of a multi‐agent chemotherapy protocol combining dexamethasone, melphalan, actinomycin D, and cytarabine for the treatment of resistant canine non‐Hodgkin high‐grade lymphomas: a single centre's experience
Autor: Smallwood, Katherine ; Tanis, Jean‐Benoit ; Grant, Iain A. ; Blackwood, Laura ; Killick, David R. ; Amores‐Fuster, Isabel ; Elliott, James ; Mas, Aran ; Harper, Aaron ; Marrington, Mary ; Finotello, Riccardo
Assuntos: actinomycin‐D ; Animals ; Antibiotics, Antineoplastic - pharmacology ; Antimetabolites, Antineoplastic - pharmacology ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents, Alkylating - pharmacology ; Antineoplastic Agents, Hormonal - pharmacology ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; canine lymphoma ; chemotherapy ; Cohort Studies ; Cytarabine - pharmacology ; Dactinomycin - pharmacology ; Databases, Factual ; Dexamethasone - pharmacology ; DMAC ; dog ; Dog Diseases - drug therapy ; Dogs ; Female ; Kaplan-Meier Estimate ; Lymphoma, Non-Hodgkin - drug therapy ; Lymphoma, Non-Hodgkin - veterinary ; Male ; melphalan ; Melphalan - pharmacology ; Neoplasm Recurrence, Local - drug therapy ; Neutropenia - veterinary ; Remission Induction ; rescue ; resistant lymphoma ; Schools, Veterinary ; Thrombocytopenia - veterinary ; Treatment Outcome ; United Kingdom
É parte de: Veterinary & comparative oncology, 2019-06, Vol.17 (2), p.165-173
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The DMAC protocol (dexamethasone, melphalan, actinomycin‐D, cytarabine) has been evaluated in American studies for the treatment of relapsed canine lymphoma, comparing similarly to other rescue protocols. The aim of this study was to evaluate efficacy and toxicity of DMAC, in a larger UK cohort of resistant canine lymphomas. Medical records of dogs with resistant non‐Hodgkin high‐grade lymphomas that received DMAC as a rescue protocol were reviewed from 2007 to 2017. Response, time from initiation to discontinuation (TTD) and toxicity (Veterinary Cooperative Oncology Group criteria) were assessed. One hundred dogs were included; 86 received CEOP (modified CHOP including epirubicin) as first‐line treatment. Thirty‐five dogs (35%) responded: 21 complete responders (CRs) and 14 partial responders (PRs). Responders had significantly longer TTD (P < 0.001) compared with non‐responders: 62 days (range 28‐952) for CR vs 32 days (range 20‐70) for PR. Six CR received more than six cycles of DMAC (range 7‐36 cycles) and experienced a longer TTD (median 508, range 126‐952 days). Thrombocytopenia occurred in 45% (24 grade 1‐2, 21 grade 3‐4) and neutropenia in 36% of cases (29 grade 1‐2, 7 grade 3‐4). Gastrointestinal toxicity occurred in 42% of dogs (40 grade 1‐2, 2 grade 3‐4). Owing to chemotherapy toxicity, treatment was discontinued in five, and hospitalization required in six cases. In this study, response to DMAC was lower and of generally shorter duration than previously reported. Toxicity was high, but infrequently led to hospitalization or discontinuation of treatment.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Evaluation of a multi‐agent chemotherapy protocol combining dexamethasone, melphalan, actinomycin D, and cytarabine for the treatment of resistant canine non‐Hodgkin high‐grade lymphomas: a single centre's experience

Smallwood, Katherine ; Tanis, Jean‐Benoit ; Grant, Iain A. ; Blackwood, Laura ; Killick, David R. ; Amores‐Fuster, Isabel ; Elliott, James ; Mas, Aran ; Harper, Aaron ; Marrington, Mary ; Finotello, Riccardo

Oxford, UK: Blackwell Publishing Ltd

Buscando em bases de dados remotas. Favor aguardar.