Language:

Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease

Costa Pereira, Cristiana ; Durães, Cecília ; Coelho, Rosa ; Grácio, Daniela ; Silva, Marco ; Peixoto, Armando ; Lago, Paula ; Pereira, Márcia ; Catarino, Telmo ; Pinho, Salomé ; Teixeira, João Paulo ; Macedo, Guilherme ; Annese, Vito ; Magro, Fernando Green, John

PloS one, 2017-01, Vol.12 (1), p.e0169102 [Peer Reviewed Journal]

United States: Public Library of Science

Full text available

Citations Cited by

Actions
1. Add to e-Shelf
2. Remove from e-Shelf
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
Author: Costa Pereira, Cristiana ; Durães, Cecília ; Coelho, Rosa ; Grácio, Daniela ; Silva, Marco ; Peixoto, Armando ; Lago, Paula ; Pereira, Márcia ; Catarino, Telmo ; Pinho, Salomé ; Teixeira, João Paulo ; Macedo, Guilherme ; Annese, Vito ; Magro, Fernando
Green, John
Subjects: Adult ; Aged ; Antioxidants ; Antioxidants (Nutrients) ; Biology and Life Sciences ; Cancer ; Carcinogenesis ; Carcinogens ; Chronic illnesses ; Colitis, Ulcerative - genetics ; Crohn Disease - genetics ; Crohns disease ; Disease control ; Disease susceptibility ; Environmental health ; Enzymes ; Female ; Gastroenterology ; Genes ; Genetic aspects ; Genetic diversity ; Genetic Predisposition to Disease - genetics ; Genetic variance ; Genomics ; Genotype ; Genotypes ; Glutathione Peroxidase - genetics ; Glutathione Peroxidase GPX1 ; Humans ; Hydrogen peroxide ; Immunology ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - genetics ; Intestine ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mucosa ; Oxidation ; Oxidative stress ; Pathogenesis ; Pathology ; Polymorphism, Single Nucleotide - genetics ; Public health ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Superoxide dismutase ; Superoxide Dismutase - genetics ; Ulcerative colitis
Is Part Of: PloS one, 2017-01, Vol.12 (1), p.e0169102
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: CCP FM.Data curation: CCP CD FM.Formal analysis: CCP CD FM.Funding acquisition: CCP.Investigation: CCP CD RC DG MS AP PL MP TC SP FM.Methodology: CCP CD FM.Project administration: FM.Resources: RC DG MS AP PL MP TC FM.Supervision: FM.Validation: CD VA.Visualization: CCP CD FM.Writing – original draft: CCP CD.Writing – review & editing: CCP CD SP JPT GM VA FM.
Competing Interests: Prof. Magro has received fees for speaking engagements from ScheringPlough/MSD, Abbvie, Lab Vitoria, and Dr. Falk Pharma Portugal, and fees for consultancies and honoraria from MSD. The other authors state no conflicts of interest concerning this paper. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Description: Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.
Publisher: United States: Public Library of Science
Language: English

Links

View this record in MEDLINE/PubMed

Back to results list

Previous Result 7 Next Go to Next page

Implemented by: Social Network Logos:

Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease

Costa Pereira, Cristiana ; Durães, Cecília ; Coelho, Rosa ; Grácio, Daniela ; Silva, Marco ; Peixoto, Armando ; Lago, Paula ; Pereira, Márcia ; Catarino, Telmo ; Pinho, Salomé ; Teixeira, João Paulo ; Macedo, Guilherme ; Annese, Vito ; Magro, Fernando Green, John

United States: Public Library of Science

Searching Remote Databases, Please Wait