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Kinetic Study of CO 2 Hydration by Small-Molecule Catalysts with A Second Coordination Sphere that Mimic the Effect of the Thr-199 Residue of Carbonic Anhydrase

Park, DongKook ; Lee, Man Sig

Biomimetics (Basel, Switzerland), 2019-10, Vol.4 (4) [Periódico revisado por pares]

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Título:
Kinetic Study of CO 2 Hydration by Small-Molecule Catalysts with A Second Coordination Sphere that Mimic the Effect of the Thr-199 Residue of Carbonic Anhydrase
Autor: Park, DongKook ; Lee, Man Sig
É parte de: Biomimetics (Basel, Switzerland), 2019-10, Vol.4 (4)
Descrição: Zinc complexes were synthesized as catalysts that mimic the ability of carbonic anhydrase (CA) for the CO hydration reaction (H O + CO → H + HCO ). For these complexes, a tris(2-pyridylmethyl)amine (TPA) ligand mimicking only the active site, and a 6-((bis(pyridin-2-ylmethyl)amino)methyl)pyridin-2-ol (TPA-OH) ligand mimicking the hydrogen-bonding network of the secondary coordination sphere of CA were used. Potentiometric pH titration was used to determine the deprotonation ability of the Zn complexes, and their p values were found to be 8.0 and 6.8, respectively. Stopped-flow spectrophotometry was used to confirm the CO hydration rate. The rate constants were measured to be 648.4 and 730.6 M s , respectively. The low p value was attributed to the hydrogen-bonding network of the secondary coordination sphere of the catalyst that mimics the behavior of CA, and this was found to increase the CO hydration rate of the catalyst.
Editor: Switzerland
Idioma: Inglês

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